| 產(chǎn)品編號 | bsm-61899R |
| 英文名稱 | UCP1/3 Recombinant Rabbit mAb |
| 中文名稱 | 線粒體脫偶連蛋白1/3重組兔單抗 |
| 別 名 | UCP1; UCP3. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 5F19 |
| 交叉反應(yīng) | Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IP=1:20-50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 33,34 kDa |
| 檢測分子量 | 34 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse UCP1/3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Mitochondrial transporter that functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. SWISS: P12242 Gene ID: 22227 線粒體及Cyto-c在細(xì)胞凋亡中的中心地位雖然在不同信號誘導(dǎo)的細(xì)胞凋亡具有一定意義，但線粒體作為細(xì)胞內(nèi)死亡信號的感受者和放大者在細(xì)胞凋亡中的重要性是勿庸置疑的。 線粒體由兩層膜包被,外膜平滑,內(nèi)膜向內(nèi)折疊形成嵴,兩層膜之間有腔,線粒體中央是基質(zhì)。基質(zhì)內(nèi)含 有與三羧酸循環(huán)所需的全部酶類,內(nèi)膜上具有呼吸鏈酶系及ATP酶復(fù)合體。線粒體能為細(xì)胞的生命活動提供場所，是細(xì)胞內(nèi)氧化磷酸化和形成ATP的主要場所。另外,線粒體有自身的DNA和遺傳體系, 但線粒體基因組的基因數(shù)量有限,因此,線粒體只是一種半自主性的細(xì)胞器。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with UCP1/3 monoclonal antibody, unconjugated (bsm-61899R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
|
