| 產(chǎn)品編號(hào) | bsm-62258R |
| 英文名稱 | Phospho-GSK3 A/B (Tyr279/Tyr216) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化糖原合酶激酶3α/β重組兔單抗 |
| 別 名 | Glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK3A. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,ICC/IF=1:50-1:200,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 51,47 kDa |
| 檢測(cè)分子量 | 51,46 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GSK3 alpha around the phosphorylation site of Y279 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
GSK3A a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase. SWISS: P49840 Gene ID: 2931 組成性活性蛋白激酶，通過磷酸化和失活糖原合成酶（GYS1或GYS2）、CTNNB1/β連環(huán)蛋白、APC和AXIN1，在激素控制葡萄糖穩(wěn)態(tài)、Wnt信號(hào)傳導(dǎo)和轉(zhuǎn)錄因子及微管的調(diào)節(jié)中作為負(fù)調(diào)節(jié)因子。它的大多數(shù)底物需要啟動(dòng)磷酸化。通過磷酸化和抑制GYS1活性從而促進(jìn)糖原合成的胰島素調(diào)節(jié)。調(diào)節(jié)肝臟的糖原代謝，而不是肌肉。也可能通過調(diào)節(jié)轉(zhuǎn)錄因子的激活來介導(dǎo)胰島素抵抗的發(fā)展。在Wnt信號(hào)中，調(diào)節(jié)核CTNNB1/β連環(huán)蛋白的水平和轉(zhuǎn)錄活性。促進(jìn)淀粉樣前體蛋白（APP）的加工和阿爾茨海默病APP源性淀粉樣斑塊的形成?？赡軈? |
| 產(chǎn)品圖片 |
Western blot analysis of 293 cell lysate treated with AP. Using Phospho-GSK3 A/B (Tyr279/Tyr216) (bsm-62258R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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