强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品国产人妻AV多野结衣,日本强伦轩人妻中文字幕
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
GRP78 Rabbit pAb (bs-1219R)  
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢(xún)價(jià)

產(chǎn)品編號(hào) bs-1219R
英文名稱(chēng) GRP78 Rabbit pAb
中文名稱(chēng) 葡萄糖調(diào)節(jié)蛋白78/熱休克蛋白70蛋白5抗體
別    名 BIP; HSPA5; GRP-78; glucose regulated protein 78; 78 kDa glucose regulated protein; BIP; Endoplasmic reticulum lumenal Ca2+binding protein grp78; FLJ26106; Glucose Regulated Protein 78kDa; GRP 78; Heat Shock 70kDa Protein 5; HSPA 5; HSPA-5; Immunoglobulin Heavy Chain Binding Protein; MIF2; GRP78_HUMAN.  
Specific References  (34)     |     bs-1219R has been referenced in 34 publications.
[IF=7.675] Reziyamu Wufuer. et al. Distinct Roles of Nrf1 and Nrf2 in Monitoring the Reductive Stress Response to Dithiothreitol (DTT). ANTIOXIDANTS-BASEL. 2022 Aug;11(8):1535  WB ;  Human.  
[IF=6.208] Yu Wu. et al. Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia–Reperfusion Injury via the PERK-ATF4-CHOP Pathway. INT J MOL SCI. 2023 Jan;24(1):544  WB ;  Rat.  
[IF=5.96] Xia, Dan, et al. "Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress." Cell Death and Disease 8.7 (2017).  WB ;  Human.  
[IF=5.878] Xueying Zhang. et al. Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway. 2021 Dec 02  WB ;  Mouse ,Human.  
[IF=5.391] Zhou L et al. KLF15-activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF-κB-FGF21 or SREBP1c-FGF21 pathway. FASEB J. 2019 Oct 24:fj201901347RR.  WB ;  Mouse&Human.  
[IF=5.19] Peng Junjun. et al. Mitochondria-associated endoplasmic reticulum membranes participate mitochondrial dysfunction and endoplasmic reticulum stress caused by copper in duck kidney. ENVIRON SCI POLLUT R. 2023 May;:1-12  WB ;  Duck.  
[IF=4.868] Cui J et al. Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress-and Ca2. Oxid Med Cell Longev. 2019 Jan 9;2019:2593742.  WB ;  Mouse.  
[IF=4.557] Zhao,et al.Osteopontin contributes to effective neutrophil recruitment, IL-1β production and apoptosis in Aspergillus fumigatus keratitis.(2018) Immunology and Cell Biology. 96:401-412.  IF(IHC-F) ;  Mouse.  
[IF=4.52] Zhu YP et al. Unification?of?Opposites?between?Two?Antioxidant?Transcription?Factors?Nrf1?and?Nrf2?in?Mediating?Distinct?Cellular?Responses?to the?Endoplasmic?Reticulum?Stressor?Tunicamycin. Antioxidants (Basel). 2019 Dec 19;9(1). pii: E4.  WB ;  Human.  
[IF=4.302] Zuo L et al. PI3-kinase/Akt?pathway-regulated?membrane?transportation?of?acid-sensing?ion?channel1a/Calcium?ion?influx/endoplasmic?reticulum?stress?activation?on?PDGF-induced HSC?Activation. J Cell Mol Med. 2019 Apr 2.  IHC-P ;  Human.  
[IF=4.014] Xueping Chen. et al. Baicalin ameliorates Mycoplasma gallisepticum-induced inflammatory injury via inhibiting STIM1-regulated ceramide accumulation in DF-1 cells. POULTRY SCIENCE. 2023 Mar;:102687  WB ;  Chicken.  
[IF=3.858] Li,et al.Silver nanoparticles induce SH-SY5Y cell apoptosis via endoplasmic reticulum- and mitochondrial pathways that lengthen endoplasmic reticulum-mitochondria contact sites and alter inositol-3-phosphate receptor function.(2018) Toxicology Letters. 285:156-167.  WB ;  Human.  
[IF=3.827] Yuan, Naihan. et al. Replication of standard bovine viral diarrhea strain OregonC24Va induces endoplasmic reticulum stress–mediated apoptosis of bovine trophoblast cells. CELL STRESS CHAPERON. 2022 Nov;:1-12  WB ;  Bovine.  
[IF=3.642] Emin Kaymak. et al. Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin. 2021 Aug 15  IHC ;  Rat.  
[IF=3.606] Xuejiao Zhou. et al. The novel ALK inhibitor ZX‐29 induces apoptosis through inhibiting ALK and inducing ROS‐mediated endoplasmic reticulum stress in Karpas299 cells. 2020 Nov 02  WB ;  Human.  
[IF=3.606] Derya Karabulut. et al. Thymoquinone attenuates doxorubicin‐cardiotoxicity in rats. J Biochem Mol Toxic. 2021 Jan;35(1):e22618  IHC ;  Rat.  
[IF=3.37] Du, Shaoqing, et al. "SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis." Archives of biochemistry and biophysics 502.2 (2010): 137-143.  WB ;  Human.  
[IF=3.28] Chen, Li, et al. "Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid." Endocrine (2016): 1-13.  WB ;  Mouse.  
[IF=3.219] Yuting Li. et al. Evodiamine suppresses the progression of non-small cell lung carcinoma via endoplasmic reticulum stress-mediated apoptosis pathway in vivo and in vitro:. INT J IMMUNOPATH PH. Int J Immunopath Ph. 2022;():  WB ;  Human,Mouse.  
[IF=3.076] Tang Q et al. Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure.Neurotoxicology. 2018 Jul;67:27-36.  WB ;  Mouse.  
[IF=3.046] Yong-yi Dai. et al. Effects of exogenous vitamin D on endoplasmic reticulum stress-related factors in the vitamin D deficiency rats with cerebral ischemia. Neurosci Lett. 2021 Jul;:136115  WB ;  Rat.  
[IF=2.776] Su M et al.Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress. (2019) Environ Toxicol Pharmacol.65:60-65.  WB ;  Mouse.  
[IF=2.776] He?Q et al. Titanium dioxide nanoparticles induce mouse hippocampal neuron apoptosis via oxidative stress- and calcium imbalance-mediated endoplasmic reticulum stress. Environ Toxicol Pharmacol. 2018 Oct;63:6-15.  WB ;  Mouse.  
[IF=2.77] Zuo Y et al. Preoperative vitamin-rich carbohydrate loading alleviates postoperative cognitive dysfunction in aged rats. Behav Brain Res. 2019 Nov 5;373:112107.  WB ;  Rat.  
[IF=2.71] Wei, W, et al. "Excessive fluoride induces endoplasmic reticulum stress and interferes enamel proteinases secretion." Environmental Toxicology 28 (2013):  Human.  
[IF=2.611] Ozturk, E.. et al. Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity. 2021 Oct 16  IHC ;  Rat.  
[IF=2.147] Gurur Garip. et al. Effect of endoplasmic reticulum stress on human trophoblast cells: Survival triggering or catastrophe resulting in death. ACTA HISTOCHEM. 2022 Oct;124:151951  IF ;  Human.  
[IF=1.954] Jiang H et al.Strontium Alleviates Endoplasmic Reticulum Stress in a Nonalcoholic Fatty Liver Disease Model.(2018)J Med Food. Nov 17.  IHC ;  Rat.  
[IF=1.851] Lan J et al. Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A. Molecular Medicine Reports 21.2 (2020): 567-574.  WB ;  Rat.  
[IF=1.834] Emin Kaymak. et al. Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis. BIOTECH HISTOCHEM. 2022 Aug 22  IHC ;  Mouse.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human,Rat (predicted: Mouse,Pig)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 78 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRP78: 251-360/654 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Similarity:
Belongs to the heat shock protein 70 family.

SWISS:
P11021

Gene ID:
3309

Database links:

Entrez Gene: 3309 Human

Entrez Gene: 14828 Mouse

Entrez Gene: 25617 Rat

Omim: 138120 Human

SwissProt: P11021 Human

SwissProt: P20029 Mouse

SwissProt: P06761 Rat

Unigene: 605502 Human

Unigene: 743241 Human

Unigene: 330160 Mouse

Unigene: 470180 Mouse

Unigene: 11088 Rat



葡萄糖調(diào)節(jié)蛋白78是熱休克蛋白70家族的成員之一,又稱(chēng):熱休克蛋白70蛋白5,作為一種分子伴侶在蛋白質(zhì)的折疊和轉(zhuǎn)運(yùn)過(guò)程及內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)中發(fā)揮重要作用.它在多種腫瘤組織中呈高表達(dá).
產(chǎn)品圖片
Sample: Lane 1: Spleen (Rat) Lysate at 40 ug Lane 2: Cerebrum (Rat) Lysate at 40 ug Lane 3: U-87MG (Human) Cell Lysate at 30 ug Lane 4: Hela (Human) Cell Lysate at 30 ug Lane 5: HepG2 (Human) Cell Lysate at 30 ug Lane 6: MDA-MB-231 (Human) Cell Lysate at
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30mi
Tissue/cell: rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat s
版權(quán)所有 2004-2026 www.nmgps.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日本黑人乱偷人妻中文字幕 | 少妇被又大又粗又爽毛片久久黑人 | 成人视频免费在线观看 | 91l九色l刺激黑人 | 免费无码婬片AAAA片 | 国产最爽乱婬视频播放 | 园产乱人乱偷精品视频 | 大学生一次一片免费 | 韩国一级婬片免费看 | 亚洲无码一区二区在线观看 | 少妇性BBB搡BBB爽爽爽四川 | 国产精品久久久久久久一区探花 | 成人免费A片在线观看直播96 | 免费看无码一级A片放24小时 | 国产91 丝袜在线播放九色 | 安徽丰满少妇BBBBBB | 虎色视频成人版免费 | 特级老太婆婬片A片 | 国语对白做受 欧美 | 一级A片高龄老妇毛多多 | 久久久久久久久久久国产 | 韩国少妇BBB毛毛片 四川BBB搡BB水多 | 成人免费黃色欧美大片 | 国产愉拍91九色国产愉拍 | 久久久久久久久成人精品视频 | 1000部做爰免费视频 | 亚洲中文字幕无限乱码 | 911亚洲精品无码成人A片在线 | 精品久久久久久久成人热 91 | 国产jk白丝美女自慰漫画在线观看 | 日韩AV一区二区三区 | 日本美女一级在线观看网站 | 欧美熟妇A片在线观看麻豆 色乱一区二区三区四区五匹 | 成人做爰黄 片视频真人 | 欧美人妻精品久久久久久 | 久久久久久久久金莲tb | 国产精品无码久久打开 | 国产精品无码免费视频 | 色综合久久天天综合网 | 三亚三黄三色AAA毛片 | 三级三级三级A级全黄公司的 |