| 產(chǎn)品編號 | bs-0540R |
| 英文名稱 | HAI-1 Rabbit pAb |
| 中文名稱 | 肝細(xì)胞生長因子激活物抑制劑/HGFA Inhibitor 1抗體 |
| 別 名 | Hepatocyte Growth Factor Activator Inhibitor 1; Spint1; Hai1; HGFA Inhibitor 1; HAI-1; SPIT1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 激酶和磷酸酶 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 55 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HAI-1: 451-529/529 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence. Function: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). Subunit: Interacts with HGFAC. Subcellular Location: Secreted. Similarity: Contains 2 BPTI/Kunitz inhibitor domains. Contains 1 LDL-receptor class A domain. Contains 1 MANSC domain. SWISS: O43278 Gene ID: 6692 Database links: Entrez Gene: 6692 Human Omim: 605123 Human SwissProt: O43278 Human Unigene: 233950 Human HAI-1 是一種含兩個 Kunitz 域的跨膜蛋白，可抑制由細(xì)胞膜分泌的并且以游離形式存在的 HGFA 。 HAI-1 也可以作用于其它絲氨酸蛋白酶. HAI-1 主要在胎盤、腎、胰腺、前列腺和小腸，也有報道稱 HAI-1 會在肝癌中表達(dá)。 |
| 產(chǎn)品圖片 |
Sample:
Pancreas (Mouse) Lysate at 40 ug
Primary: Anti- HAI-1 (bs-0540R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
|
