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IL-1R1 Rabbit pAb (bs-2594R)  
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產(chǎn)品編號 bs-2594R
英文名稱 IL-1R1 Rabbit pAb
中文名稱 白介素1受體1抗體
別    名 Antigen CD121a; CD121 antigen-like family member A; CD121A; CD121a antigen; D2S1473; IL 1; IL 1R 1; IL 1R alpha; IL 1RT1; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; IL1 inhibitor; IL1R; IL1R1; IL1R1_HUMAN; IL1RA; IL1RN; IL1RT1; Interleukin 1 receptor alpha type 1; Interleukin 1 receptor antagonist protein(IRAP); Interleukin 1 receptor type I; Interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; P80; IL1 Receptor I; IL-1 Receptor I; Interleukin-1 receptor type 1, soluble form; IL-1 sRI.  
Specific References  (3)     |     bs-2594R has been referenced in 3 publications.
[IF=6.025] Xuliang Zhang. et al. PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity. FOOD CHEM TOXICOL. 2022 Jun;164:113078  WB ;  Mouse.  
[IF=5.682] Pan, Jingrui. et al. Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6. MOL NEUROBIOL. 2023 Jan;:1-18  WB,IF ;  Rat.  
[IF=4.427] Zhang?H et al. Aluminum trichloride-induced hippocampal inflammatory lesions are associated with IL-1β-activated IL-1 signaling pathway in developing rats. Chemosphere. 2018 Jul;203:170-178.  WB ;  Rat.  
研究領域 心血管  免疫學  干細胞  淋巴細胞  t-淋巴細胞  細胞因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat)
產(chǎn)品應用 WB=1:500-2000,Flow-Cyt=1μg /test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 63 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-1R1: 481-569/569 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II(IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq].

Function:
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Subunit:
The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted.

Post-translational modifications:
A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).

Similarity:
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.

SWISS:
P14778

Gene ID:
3554

Database links:

Entrez Gene: 3554 Human

Entrez Gene: 16177 Mouse

Entrez Gene: 25663 Rat

Omim: 147810 Human

SwissProt: P14778 Human

SwissProt: P13504 Mouse

SwissProt: Q02955 Rat

Unigene: 516249 Human

Unigene: 701982 Human

Unigene: 896 Mouse

Unigene: 9758 Rat



IL-1RⅠ屬于新的信號受體家族Toll信號轉(zhuǎn)導通路蛋白,IL-1RⅠ在免疫和炎癥反應的研究中占重要地位,是在很多感染 、炎癥性致病機制中起決定性作用的細胞因子,幾乎可作用于全身各種細胞,IL-1 與IL-1R1的結(jié)合可導致大量與免疫反應和炎癥相關基因的表達 ,包括細胞因子、細胞因子受體、急性期反應物、生長因子、胞外基質(zhì)、粘附分子等。IL-1R1/NF-κB信號通路是機體免疫反應中十分重要的組成部分。白介素1受體I型 Interleukin 1 receptor I(IL-1RI)
產(chǎn)品圖片
Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-IL-1R1 (bs-2594R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kD Observed band size: 63 kD
Blank control (blue line): MCF7 (blue). Primary Antibody (green line): Rabbit Anti-IL-1R1 antibody (bs-2594R); Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE; Dilution: 1μg /test. Protocol The cells were fixed with 70% methanol overnight at 4℃ . Cells stained with Primary Antibody for 30 min at room temperature. The cells were then incubated in 1 X PBS/2%BSA/10% goat serum to block non-specific protein-protein interactions followed by the antibody for 15 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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