| 產(chǎn)品編號(hào) | bs-2438R |
| 英文名稱 | AVEN Rabbit pAb |
| 中文名稱 | 細(xì)胞死亡調(diào)節(jié)劑Aven抗體 |
| 別 名 | AVEN_HUMAN; Cell death regulator Aven; apoptosis and caspase activation inhibitor; PDCD12; |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 38 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AVEN: 301-362/362 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients. Function: Protects against apoptosis mediated by Apaf-1 Subunit: Binds Apaf-1, BCL-2 and BAD (Bcl-xl) Subcellular Location: Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes. Tissue Specificity: Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas. SWISS: Q9NQS1 Gene ID: 57099 Database links: Entrez Gene: 57099 Human Entrez Gene: 74268 Mouse Omim: 605265 Human SwissProt: Q9NQS1 Human SwissProt: Q9D9K3 Mouse Unigene: 555966 Human Unigene: 315125 Mouse Unigene: 436657 Mouse Unigene: 145049 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Cerebellum tissue lysates
Lane 2: Rat Spleen tissue lysates
Primary: Anti-AVEN (bs-2438R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38 kDa
Observed band size: 52 kDa
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