| 產(chǎn)品編號 | bs-2171R |
| 英文名稱 | URG4 Rabbit pAb |
| 中文名稱 | 乙型肝炎病毒X蛋白上調(diào)基因4 |
| 別 名 | FLJ20654; HBV X protein up-regulated gene 4 protein; HBV X protein upregulated gene 4 protein; HBxAg up-regulated gene 4 protein; HBxAg upregulated gene 4 protein; KIAA1507; Up-regulator of cell proliferation; Upregulated gene 4; Upregulator of cell proliferation; URGCP; URGCP_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 細胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 105 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human URG4: 1-100/931 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008] Function: May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. Subcellular Location: Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei. Tissue Specificity: Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines. SWISS: Q8TCY9 Gene ID: 55665 Database links: Entrez Gene: 55665 Human Omim: 610337 Human SwissProt: Q8TCY9 Human Unigene: 709317 Human HBx是HBV感染、復(fù)制、發(fā)病和可能致癌關(guān)鍵蛋白,是具有多種功能的病毒調(diào)節(jié)因子,在慢性HBV感染的病程中占有舉足輕重的作用 。URG4(Upregulated gene 4)也是一個從肝癌細胞中克隆出來的可以被HBx蛋白上調(diào)的新分子，URG4過量表達在乙型肝炎感染和肝癌細胞中。 |
