| 產(chǎn)品編號 | bs-3902R |
| 英文名稱 | Dio3 Rabbit pAb |
| 中文名稱 | 甲狀腺素5'脫碘酶3抗體 |
| 別 名 | Type 3 DI; D3; 5DIII; Deiodinase iodothyronine type 3; Deiodinase iodothyronine type III; Dio 3; DIOIII; MGC124117; MGC124118; TXDI3; Type III 5' deiodinase; Type III iodothyronine deiodinase. |
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Specific References (1) | bs-3902R has been referenced in 1 publications.
[IF=6.551] Mei Ha. et al. PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism. Sci Total Environ. 2021 Feb;757:143727 WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號 生長因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dio3: 51-150/278 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Dio3 belongs to the iodothyronine deiodinase family. It has an essential role for regulation of thyroid hormone inactivation during embryological development in that it catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Dio3 may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones and has been linked to the development of consumptive hypothyroidism in both infants and adults. Subunit: Homodimer. May undergo minor heretodimerization with DIO1 and DIO2. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Tissue Specificity: Expressed in placenta and several fetal tissues. Similarity: Belongs to the iodothyronine deiodinase family. SWISS: P55073 Gene ID: 1735 Database links: Entrez Gene: 1735 Human Entrez Gene: 107585 Mouse Omim: 601038 Human SwissProt: P55073 Human SwissProt: Q91ZI8 Mouse Unigene: 49322 Human Unigene: 154427 Mouse |
| 產(chǎn)品圖片 |
Sample: JAR Cell (Human) Lysate at 40 ug
Primary: Anti-Dio3 (bs-3902R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD
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