| 產(chǎn)品編號(hào) | bs-5778R |
| 英文名稱 | TGFB4/LEFTY2 Rabbit pAb |
| 中文名稱 | 轉(zhuǎn)化生長(zhǎng)因子β4抗體 |
| 別 名 | EBAF; Endometrial bleeding associated factor(left right determination factor A transforming growth factor beta superfamily); Endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left right determination factor 2; Left right dete |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TGFB4: 281-366/366 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
LEFTY2 is a member of the TGF-beta family of proteins. LEFTY2 is secreted and plays a role in left-right asymmetry determination of organ systems during development and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Function: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Subcellular Location: Secreted. Tissue Specificity: Mesenchymal cells of the endometrial stroma. Post-translational modifications: The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. DISEASE: Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Similarity: Belongs to the TGF-beta family. SWISS: O00292 Gene ID: 7044 Database links: Entrez Gene: 7044 Human Entrez Gene: 320202 Mouse Omim: 601877 Human SwissProt: O00292 Human SwissProt: P57785 Mouse Unigene: 520187 Human Unigene: 87078 Mouse Unigene: 215726 Rat |
| 產(chǎn)品圖片 |
Sample:
A431(Human) Cell Lysate at 30 ug
Primary: Anti-LEFTY2? (bs-5778R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 32 kD
Observed band size: 32 kD
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