| 產(chǎn)品編號 | bs-7536R |
| 英文名稱 | SERPINA12 Rabbit pAb |
| 中文名稱 | 內(nèi)臟脂肪組織源性絲氨酸蛋白酶抑制蛋白抗體 |
| 別 名 | OL 64; OL-64; OL64; Serine(or cysteine) proteinase inhibitor clade A(alpha 1 antiproteinase antitrypsin) member 12; Serpin A12; Serpin A12 precursor; Serpin peptidase inhibitor clade A(alpha 1 antiproteinase antitrypsin) member 12; SPA12_HUMAN antibody Vaspin; Visceral adipose specific serpin; Visceral adipose tissue derived serine protease inhibitor; Visceral adipose tissue-derived serine protease inhibitor; Visceral adipose-specific serpin. |
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Specific References (1) | bs-7536R has been referenced in 1 publications.
[IF=1.07] Bao et al. Expression of vaspin in the joint and the levels in the serum and synovial fluid of patients with osteoarthritis. (2014) Int.J.Clin.Exp.Me. 7:3447-53 IHC ; Human.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SERPINA12/Vaspin |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and tumor suppressor genes (maspin). Most inhibitory serpins target chymotrypsin-like serine proteases. These enzymes are defined by the presence of a nucleophilic serine residue in their catalytic site. Some serpins inhibit other classes of protease. A number of such serpins have been shown to target cysteine proteases. These enzymes differ from serine proteases in that they are defined by the presence of a nucleophilic cysteine residue, rather than a serine residue, in their catalytic site. SerpinA12, also known as OL-64, Visceral adipose tissue-derived serine protease inhibitor, Vaspin, Visceral adipose-specific serpin and SERPINA12, is a secreted protein which belongs to the serpin family. SerpinA12 / Vaspin is expressed in visceral adipose tissues. It may modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. SerpinA12 / Vaspin may be the compensatory molecule in the pathogenesis of metabolic syndrome and SerpinA12 / Vaspin recombinant protein or vaspin-mimicking agents such as vaspin analogs, antibodies or small molecule agents may be the link to drug discovery and development. Function: May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. Subcellular Location: Secreted. Tissue Specificity: Expressed in visceral adipose tissues. Similarity: Belongs to the serpin family. SWISS: Q8IW75 Gene ID: 145264 Database links: Entrez Gene: 145264 Human SwissProt: Q8IW75 Human Unigene: 99476 Human
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| 產(chǎn)品圖片 |
Sample:
Lane 1: Human HepG2 cell lysates
Lane 2: Human MCF-7 cell lysates
Lane 3: Human U-2 OS cell lysates
Primary: Anti-SERPINA12 (bs-7536R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kDa
Observed band size: 45 kDa
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