| 產(chǎn)品編號 | bs-6846R |
| 英文名稱 | Nucleostemin Rabbit pAb |
| 中文名稱 | 核干細(xì)胞因子鳥嘌呤核苷酸結(jié)合蛋白3抗體 |
| 別 名 | E2 induced gene 3 protein; E2IG3; Estradiol induced nucleotide binding protein; GNL3; Guanine nucleotide binding protein like 3(nucleolar); Guanine nucleotide binding protein like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP binding protein 3; Nucleostemin; Putative nucleotide binding protein estradiol induced; C77032; GNL3_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 干細(xì)胞 細(xì)胞類型標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Pig,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 62 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nucleostemin: 101-160/548 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Nucleostemin is a protein found in the nucleoli of embryonic stem cells, adult CNS stem cells, primitive cells in the bone marrow and cancer cells. It is not in the differentiated cells of most adult tissues. It has been suggested to play a role in controlling the cell cycle progression in stem cells and cancer cells. Function: May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis. Subunit: Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity). Subcellular Location: Nucleus. Nucleus. nucleolus. Shuttles between the nucleus and nucleolus. Tissue Specificity: Increased levels in lung tissue in cancer patients. Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family. Contains 1 G (guanine nucleotide-binding) domain. SWISS: Q9BVP2 Gene ID: 26354 Database links: Entrez Gene: 26354 Human Entrez Gene: 30877 Mouse Omim: 608011 Human SwissProt: Q9BVP2 Human SwissProt: Q8CI11 Mouse Unigene: 313544 Human Unigene: 88512 Mouse Unigene: 4110 Rat |
| 產(chǎn)品圖片 |
Sample:
Embryo(Mouse) Lysate at 40 ug
Primary: Anti- Nucleostemin (bs-6846R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 62 kD
Observed band size: 62 kD
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