| 產(chǎn)品編號(hào) | bs-7084R |
| 英文名稱 | CARD15/NOD2 Rabbit pAb |
| 中文名稱 | 凋亡加強(qiáng)結(jié)構(gòu)域蛋白15抗體 |
| 別 名 | ACUG; Arthrocutaneouveal granulomatosis; BLAU; CARD15; Caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; CD; IBD1; Inflammatory bowel disease protein 1; LRR containing protein; LRR-containing protein; Nod2; NOD2 prot |
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Specific References (1) | bs-7084R has been referenced in 1 publications.
[IF=6.208] Lan Yang. et al. Lactobacillusjohnsonii L531 Protects against Salmonella Infantis-Induced Intestinal Damage by Regulating the NOD Activation, Endoplasmic Reticulum Stress, and Autophagy. INT J MOL SCI. 2022 Jan;23(18):10395 WB ; Pig, Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 114 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CARD15: 251-350/1040 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Defects in NOD2 are the cause of sarcoidosis early-onset (EOS) . EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early-onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement. Subunit: Binds to RIPK2/RICK by CARD-CARD interaction. Subcellular Location: Cytoplasm. Tissue Specificity: Monocytes-specific. Similarity: Contains 2 CARD domains. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT domain. SWISS: Q9HC29 Gene ID: 64127 Database links: Entrez Gene: 64127 Human Entrez Gene: 257632 Mouse Omim: 605956 Human SwissProt: Q9HC29 Human SwissProt: Q8K3Z0 Mouse Unigene: 592072 Human Unigene: 222633 Mouse Unigene: 218600 Rat CARD15與家族性腸黏膜克羅恩病有關(guān)。 |
| 產(chǎn)品圖片 |
Sample:
A549(Human) Cell Lysate at 30 ug
MCF-7(Human) Cell Lysate at 30 ug
Primary: Anti-NOD2 (bs-7084R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114 kD
Observed band size: 114 kD
Sample:
MCF-7(Human) Cell Lysate at 30 ug
Primary: Anti-NOD2 (bs-7084R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114 kD
Observed band size: 114 kD
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