| 產(chǎn)品編號 | bs-4906R |
| 英文名稱 | SLC40A1 Rabbit pAb |
| 中文名稱 | 細(xì)胞膜鐵轉(zhuǎn)運(yùn)蛋白FP1抗體 |
| 別 名 | Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3. |
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Specific References (12) | bs-4906R has been referenced in 12 publications.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 63 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC40A1/FPN1: 331-430/571 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin. Function: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Subunit: Belongs to the S1LC40A transporter family. Subcellular Location: Cell membrane. Localized to the basolateral membrane of polarized epithelial cells. Tissue Specificity: Expressed in placenta, intestine, muscle and spleen. DISEASE: Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Similarity: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. SWISS: Q9NP59 Gene ID: 30061 Database links: Entrez Gene: 30061 Human Entrez Gene: 53945 Mouse Omim: 604653 Human SwissProt: Q9NP59 Human SwissProt: Q9JHI9 Mouse Unigene: 643005 Human Unigene: 28756 Mouse Unigene: 15324 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human Hepg2 cell lysates
Lane 2: Human K562 cell lysates
Lane 3: Human Molt-4 cell lysates
Lane 4: Human Jurkat cell lysates
Primary: Anti-SLC40A1 (bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kDa
Observed band size: 60 kDa
Sample:
A673(Human) Cell Lysate at 30 ug
Primary: Anti-SLC40A1?(bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kD
Observed band size: 65 kD
Sample:
K562 (Human) Cell Lysate at 30 ug
HepG2 (Human) Cell Lysate at 30 ug
Primary: Anti-SLC40A1 (bs-4906R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 63 kD
Observed band size: 63 kD
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