| 產(chǎn)品編號 | bs-11323R |
| 英文名稱 | Neuroglycan C Rabbit pAb |
| 中文名稱 | 跨膜硫酸軟骨素蛋白聚糖C抗體 |
| 別 名 | Acidic leucine rich EGF like domain containing brain protein; Acidic leucine-rich EGF-like domain-containing brain protein; Caleb; CSPG5_HUMAN. |
| 研究領(lǐng)域 | 細胞生物 神經(jīng)生物學(xué) 干細胞 細胞類型標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 57 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neuroglycan C: 351-450/566 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Neuroglycan C is a brain-specific chondroitin sulfate proteoglycan (CSPG) implicated in the proliferation of neural stem and progenitor cells. Neuro-glycan C is a single-pass membrane protein that can manifest as a part-time proteoglycan depending on the tissue expressing it. In its proteoglycan form, Neuroglycan C exhibits chondroitin sulfate glycans and functions as a receptor for midkine, a growth factor that binds heparin, to affect cytoskeletal changes. By means of ectodomain shedding, the ectodomain of Neuroglycan C is able to enhance neurite outgrowth from neurons. Neurite growth stimulation is affected by both an EGF-like and an acidic amino acid domain found on the shed ectodomain. Both domains instigate neurite growth, however, these domains exhibit differing functionality as to number of neurites produced and neuron types stimulated. Function: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. Subunit: Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. Subcellular Location: Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. In neurons, localizes to synaptic junctions (By similarity). Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts. Tissue Specificity: Restricted to brain (at protein level). Post-translational modifications: O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation. Phosphorylated; in intracellular and extracellular parts. Similarity: Contains 1 EGF-like domain. SWISS: Q49AA8 Gene ID: 10675 Database links: Entrez Gene: 10675 Human Entrez Gene: 29873 Mouse Omim: 606775 Human SwissProt: O95196 Human SwissProt: Q49AA8 Human SwissProt: Q71M36 Mouse Unigene: 45127 Human Unigene: 38496 Mouse Unigene: 10146 Rat |
| 產(chǎn)品圖片 |
Sample: U251 Cell (Human) Lysate at 40 ug
Primary: Anti-Neuroglycan C (bs-11323R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 57 kD
Observed band size: 57/65 kD
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