| 產(chǎn)品編號 | bs-15493R |
| 英文名稱 | IDO1 Rabbit pAb |
| 中文名稱 | 吲哚胺2,3-雙加氧酶抗體 |
| 別 名 | Indoleamine 2, 3-dioxygenase; 3-dioxygenase; I23O1_HUMAN; IDO 1; IDO; IDO-1; INDO; indolamine 2, 3 dioxygenase; Indole 2 3 dioxygenase; indoleamine 2 3 dioxygenase 1; indoleamine 2 3 dioxygenase; Indoleamine 2, 3-dioxygenase 1; Indoleamine pyrrole 2 3 dioxygenase; Indoleamine-pyrrole 2; indoleamine-pyrrole 2, 3 dioxygenase. |
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Specific References (5) | bs-15493R has been referenced in 5 publications.
[IF=12.441] Peng et al. Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy. (2018) Adv.Sci.(Weinh). 5:1700891 IHC,WB ; mouse.
[IF=7.376] Yunjia Li. et al. Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation. Free Radical Bio Med. 2021 Aug;172:578 IHC ; Mouse.
[IF=1.96] Fu, Jingjing, et al. "Effect of bone marrow-derived CD11b+ F4/80+ immature dendritic cells on the balance between pro-inflammatory and anti-inflammatory cytokines in DBA/1 mice with collagen-induced arthritis." Inflammation Research (2014): 1-11. Mouse.
[IF=1.632] Liu Y et al. Isolation and characterization of ovine monocyte-derived macrophages from peripheral blood.(2018)Vet Immunol Immunopathol. Nov;205:83-92. IF ; Sheep.
[IF=0.7] Jiang, N., et al. "Expression of indoleamine 2, 3-dioxygenase in a murine model of Aspergillus fumigatus keratitis."International Journal of Ophthalmology 9.4 (2016). IF(IHC-P) ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45 kDa |
| 檢測分子量 | 45 |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IDO: 101-200/403 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Similarity: Belongs to the indoleamine 2,3-dioxygenase family. SWISS: P14902 Gene ID: 3620 Database links: Entrez Gene: 3620 Human Entrez Gene: 15930 Mouse Omim: 147435 Human SwissProt: P14902 Human SwissProt: P28776 Mouse Unigene: 840 Human Unigene: 392 Mouse Unigene: 64513 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Epididymis tissue lysates
Lane 2: Human Hela cell lysates
Lane 3: Human Molt-4 cell lysates
Primary: Anti-IDO (bs-15493R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kD
Observed band size: 48 kD
Sample:
Lane 1: Mouse Placenta tissue lysates
Lane 2: Mouse Spleen tissue lysates
Lane 3: Mouse Lung tissue lysates
Lane 4: Rat Lymph node tissue lysates
Lane 5: Human Huvec cell lysates
Lane 6: Human Hela cell lysates
Lane 7: Human A431 cell lysates
Primary: Anti-IDO (bs-15493R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kD
Observed band size: 47 kD
Sample:
Lane 1: Mouse Epididymis tissue lysates
Lane 2: Human Hela cell lysates
Lane 3: Human Molt-4 cell lysates
Primary: Anti-IDO (bs-15493R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kD
Observed band size: 48 kD
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