| 產(chǎn)品編號 | bs-17904R |
| 英文名稱 | MUC17 Rabbit pAb |
| 中文名稱 | 粘蛋白17抗體 |
| 別 名 | Membrane mucin MUC17; MUC-17; MUC-3; MUC17; MUC17_HUMAN; Mucin 17, cell surface associated; Mucin-17; Secreted mucin MUC17; Small intestinal mucin MUC3; Small intestinal mucin-3. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 449 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MUC17: 4201-4493/4493 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM, Apr 2004] Function: Probably plays a role in maintaining homeostasis on mucosal surfaces. Subcellular Location: Cell membrane and Secreted. Cell membrane. Tissue Specificity: Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. Post-translational modifications: Probably cleaved within the SEA domain. N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated. Similarity: Contains 1 EGF-like domain. Contains 1 SEA domain. SWISS: Q685J3 Gene ID: 140453 Database links: Entrez Gene: 140453 Human SwissProt: Q685J3 Human Unigene: 271819 Human |
