强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
老熟女 码A片,欧美性受XXXX黑人XYX性爽,91丨国产丨白浆秘 喷淫网站
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Adiponectin Mouse mAb (bsm-10801M)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
200ug(PBS only)/5600.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bsm-10801M
英文名稱 Adiponectin Mouse mAb
中文名稱 脂聯(lián)素單克隆抗體
別    名 30 kDa adipocyte complement related protein; 30 kDa adipocyte complement-related protein; ACDC; ACRP 30; ACRP30; ADIPO_HUMAN; Adipocyte; Adipocyte C1q and collagen domain containing protein; Adipocyte complement related 30 kDa protein; Adipocyte complement related protein of 30 kDa; Adipocyte complement-related 30 kDa protein; Adiponectin; AdipoQ; Adipose most abundant gene transcript 1; Adipose most abundant gene transcript 1 protein; Adipose specific collagen like factor; ADIPQTL1; ADPN; APM 1; apM-1; ApM1; C1q and collagen domain-containing protein; GBP 28; GBP28; Gelatin binding protein; Gelatin binding protein 28; Gelatin-binding protein.  
研究領(lǐng)域 免疫學(xué)  糖尿病  內(nèi)分泌病  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 3B5
交叉反應(yīng) Human
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 25 kDa
檢測分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adiponectin 
亞    型 IgG
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Adiponectin: A protein hormone produced and secreted exclusively by adipocytes (fat cells) that regulates the metabolism of lipids and glucose. Adiponectin influences the body's response to insulin. Adiponectin also has antiinflammatory effects on the cells lining the walls of blood vessels. High blood levels of adiponectin are associated with a reduced risk of heart attack. Low levels of adiponectin are found in people who are obese (and who are at increased risk of a heart attack). Adipocytes produce and secrete a number of proteins, including leptin, adipsin, properdin, and tumor necrosis factor (TNF). An adipose tissue-specific factor was isolated and termed APM1 (AdiPose Most abundant gene transcript 1). The protein product of APM1 is adiponectin. The APM1 gene maps to chromosome 3q27.

Function:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Subunit:
Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex).

Subcellular Location:
Secreted.

Tissue Specificity:
Synthesized exclusively by adipocytes and secreted into plasma.

Post-translational modifications:
Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.
HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes (By similarity).
O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.

DISEASE:
Adiponectin deficiency (ADPND) [MIM:612556]: A condition that results in very low concentrations of plasma adiponectin. Note=The disease is caused by mutations affecting the gene represented in this entry.
Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.

SWISS:
Q15848

Gene ID:
9370

Database links:

Entrez Gene: 9370 Human

Entrez Gene: 11450 Mouse

Entrez Gene: 246253 Rat

Omim: 605441 Human

SwissProt: Q15848 Human

SwissProt: Q60994 Mouse

Unigene: 80485 Human

Unigene: 3969 Mouse



產(chǎn)品圖片
Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Adiponectin Polyclonal Antibody, Unconjugated(bs-10801M) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版權(quán)所有 2004-2026 www.nmgps.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
又大又粗又黄又爽又明的黄片 | 国产黄色高清无码小视频 | 中文字幕av免费观看 | 无码人妻一区二区三区免费京洛会 | 色五月婷婷在线观看 | 北条麻妃一区二区三区四区五区 | 国产精品成人无码a 无码 | 最好看免费中文在线看电视剧网站 | 亚洲熟妇AV一区二区三区 | 少妇搡BBBB搡BBB搡抖音 | 丰满人妻熟女aⅴ一区 | 国产老妇高潮精品A片 | 中文字幕在线免费看 | 少妇搡BBBB搡BBB搡毛茸茸 | 91大神人妻论坛性趣 | 強姦婬片A片AAA毛片Mⅴ | 黄色美女网站免费观看 | 欧美成人免费视频网址 | 又大又粗又黄国产视频 | 91精品人妻一区二区三区蜜桃 | 久久夜色精品国产网站 | 亚洲高清视频在线观看 | 免费在线观看搞骚视频 | 18岁美女污污污网站 | 五月天婷婷久久爱成人丁香网 | 亚洲午夜精品一区二区三区他趣 | 欧一美一性一交一精品 | 国产Av亚洲AⅤ高潮无 | 欧美掇BBBBB掇BBBBB | 极品人妻无人夸337p | 少妇无码又大又粗又深免小说 | 久久久久久久久久丰满 | 成人午夜婬片A片免费直播 四虎8848成人永久视频 | ,国产精品久久久久久 | 波多野结衣乳视频在线观看 | 密桃一区二区三区在线观看 | 农村寡妇婬乱A毛片 | 久久久成人网站免费观看按摩 | 国产免费AV片在线无码免费看 | 麻豆秘 在线观看国产 | 欧美一性一乱一交一视频 |