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RASA4 Rabbit pAb (bs-19732R)  
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產(chǎn)品編號(hào) bs-19732R
英文名稱 RASA4 Rabbit pAb
中文名稱 GTP酶激活蛋白樣RASA4抗體
別    名 Ca2+promoted Ras inactivator; Calcium promoted Ras inactivator; CAPRI; GAPL; RASL2_HUMAN; GTPase activating protein like; KIAA0538; MGC131890; Ras GTPase activating protein 4; RAS p21 protein activator 4; RasGAP activating like protein 2.  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 90 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RASA4: 501-600/803 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Subcellular Location:
Cytoplasm; cytosol. Cell membrane; peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Tissue Specificity:
Widely expressed.

Similarity:
Contains 1 Ras-GAP domain.

SWISS:
O43374

Gene ID:
10156

Database links:

Entrez Gene: 10156 Human

Entrez Gene: 54153 Mouse

Entrez Gene: 288589 Rat

Omim: 607943 Human

SwissProt: O43374 Human

SwissProt: Q6PFQ7 Mouse

Unigene: 696339 Human

Unigene: 290655 Mouse

Unigene: 1366 Rat



產(chǎn)品圖片
Sample:Spleen (Mouse)Lysate at 40 ug Primary: Anti-RASA4(bs-19732R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 90kD Observed band size: 90kD
Sample: HepG2 Cell (Human) Lysate at 40 ug MCF-7 Cell (Human) Lysate at 40 ug Lovo Cell (Human) Lysate at 40 ug Primary: Anti-RASA4(bs-19732R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 90kD Observed band size: 90kD
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