| 產(chǎn)品編號 | bs-21247R |
| 英文名稱 | SLC26A8 Rabbit pAb |
| 中文名稱 | 溶質(zhì)載體轉(zhuǎn)運(yùn)蛋白家族26成員8抗體 |
| 別 名 | SLC26A8; Anion exchange transporter; Anion transporter/exchanger 8; FLJ32714; MGC38861; RP11-482O9.1; Solute carrier family 26(anion exchanger) member 8; Solute carrier family 26, member 8; SPGF3; TAT1; Testis anion transporter 1. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 109 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC26A8: 801-900/970 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010] Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. Subunit: Interacts with RACGAP1. Interacts with CFTR. Subcellular Location: Membrane; Multi-pass membrane protein. Note: Located at the annulus ring structure within the sperm cell. Tissue Specificity: Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa. DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low. Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain. SWISS: Q96RN1 Gene ID: 116369 Database links: Entrez Gene: 116369 Human Omim: 608480 Human SwissProt: Q96RN1 Human Unigene: 435836 Human |
| 產(chǎn)品圖片 |
Sample:
Molt-4(Human) Cell Lysate at 30 ug
Primary: Anti- SLC26A8 (bs-21247R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 109 kD
Observed band size: 109 kD
Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti- SLC26A8 (bs-21247R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 109 kD
Observed band size: 109 kD
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