| 產(chǎn)品編號(hào) | bs-8743R |
| 英文名稱 | Synaptopodin 2 Rabbit pAb |
| 中文名稱 | 突觸足蛋白2抗體 |
| 別 名 | DKFZp686G051; Genethonin 2; Genethonin-2; Myopodin; striated muscle specific; Synaptopodin-2; SYNP2_HUMAN; SYNPO 2; Synpo2. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 結(jié)合蛋白 細(xì)胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 117 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptopodin 2: 601-700/1093 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SYNPO2 (Synaptopodin 2) is a Protein Coding gene. Diseases associated with SYNPO2 include Duchenne Muscular Dystrophy and Myopathy, Myofibrillar, 2. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is SYNPO2L. Function: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). Subcellular Location: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin. Tissue Specificity: Skeletal muscle-specific. DISEASE: Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD). Similarity: Belongs to the synaptopodin family. Contains 1 PDZ (DHR) domain. SWISS: Q9UMS6 Gene ID: 171024 Database links: Entrez Gene: 171024 Human Entrez Gene: 118449 Mouse SwissProt: Q9UMS6 Human SwissProt: Q91YE8 Mouse Unigene: 655519 Human Unigene: 317009 Mouse Unigene: 34359 Mouse Unigene: 474733 Mouse |
