| 產(chǎn)品編號 | bs-23161R |
| 英文名稱 | Cathepsin L (light chain) Rabbit pAb |
| 中文名稱 | 組織蛋白酶L抗體 |
| 別 名 | Cathepsin L light chain; CathepsinL; CATL; CTSL; CTSL protein; DKFZp686A18159; FLJ31037; Major excreted protein; MEP; cath-L; CL; CATL1_MOUSE; CathepsinL1; Cathepsin L1, Cathepsin-L1; CTSL 1; CTSL-1, CTS L1, CTS-L1. |
| 研究領(lǐng)域 | 激酶和磷酸酶 合成與降解 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 5/37 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse Cathepsin L (light chain): 251-334/334 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. Function: Important for the overall degradation of proteins in lysosomes. Subunit: Dimer of a heavy and a light chain linked by disulfide bonds. Subcellular Location: Lysosome. Similarity: Belongs to the peptidase C1 family. SWISS: P06797 Gene ID: 13039 Database links: Entrez Gene: 1514 Human Entrez Gene: 13039 Mouse Omim: 116880 Human SwissProt: P07711 Human SwissProt: P06797 Mouse Unigene: 726015 Human Unigene: 930 Mouse Unigene: 1294 Rat 合成與降解（Synthesis and Degradation） 組織蛋白酶L(cathepsin L CL)屬于木瓜蛋白酶家族中的半胱氨酸蛋白水解酶，以酶原的形式貯存于溶酶體中. 參與許多特殊的生理過程，如激素原的激活、抗原呈遞、組織器官的發(fā)育等。 在病理狀態(tài)下，因各種原因所致的細(xì)胞損傷(如病原微生物、炎癥因子、氧化應(yīng)激等)可降解細(xì)胞成分或細(xì)胞間質(zhì)基質(zhì)成分，包括層粘素、IV型膠原纖維及纖維連接素等，與人類許多疾病如腫瘤的浸潤與轉(zhuǎn)移、關(guān)節(jié)炎、骨質(zhì)疏松、阿爾茨海姆病、多發(fā)性硬化癥及其他慢性炎癥性疾病有關(guān). |
| 產(chǎn)品圖片 |
Sample:
Skin (Rat) Lysate at 40 ug
Primary: Anti- Cathepsin L (light chain) (bs-23161R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 5/37 kD
Observed band size: 47 kD
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