| 產(chǎn)品編號(hào) | bs-23839R |
| 英文名稱 | CLEC7A Rabbit pAb |
| 中文名稱 | β葡聚糖受體抗體 |
| 別 名 | CLC7A_HUMAN; C-type lectin domain family 7 member A; BGR; beta GR; CLECSF12; DECTIN1; beta-glucan receptor; beta Glucan Receptor; C-type lectin superfamily member 12; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; D |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 28 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CLEC7A: 31-130/244 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq]. Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). Subunit: Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Tissue Specificity: Detected in dendritic cells, in paracortical and medullary regions of lymph nodes, and in spleen red pulp and white pulp. Similarity: Contains 1 C-type lectin domain. SWISS: Q6QLQ4 Gene ID: 56644 Database links: Entrez Gene: 64581 Human Entrez Gene: 56644 Mouse Omim: 606264 Human SwissProt: Q9BXN2 Human SwissProt: Q6QLQ4 Mouse Unigene: 143929 Human Unigene: 239516 Mouse β-葡聚糖受體是一種非調(diào)理素依賴性受體,可在免疫反應(yīng)早期,在清除衰老細(xì)胞和防御感染方面發(fā)揮重要作用,進(jìn)而實(shí)現(xiàn)其抗腫瘤、抗感染等生物學(xué)效應(yīng)。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Blood cell lysates
Primary: Anti-CLEC7A (bs-23839R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 28 kDa
Observed band size: 42,27,21 kDa
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