| 產(chǎn)品編號(hào) | bs-21872R |
| 英文名稱 | PBK/TOPK Rabbit pAb |
| 中文名稱 | PDZ連接激酶/T-LAK細(xì)胞源蛋白激酶抗體 |
| 別 名 | TOPK; Cancer/testis antigen 84; CT84; FLJ14385; Lymphokine activated killer T cell originated protein kinase; MAPKK like protein kinase; PDZ-binding-kinase/T-LAK cell-originated protein kinase; Nori 3; Nori3; PDZ binding kinase; Serine/threonine protein k |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 36 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PBK/TOPK: 71-170/322 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Subunit : Interacts with DLG1 and TP53. Tissue Specificity: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. Post-translational modifications: Phosphorylated; in a cell-cycle dependent manner at mitosis. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain. SWISS: Q96KB5 Gene ID: 55872 Database links: Entrez Gene: 55872 Human Entrez Gene: 52033 Mouse Omim: 611210 Human SwissProt: Q96KB5 Human SwissProt: Q9JJ78 Mouse Unigene: 104741 Human Unigene: 24337 Mouse PBK/TOPK是一種新近發(fā)現(xiàn)的絲-蘇氨酸激酶,屬于MAPKK分子家族成員，具有參與調(diào)控惡性腫瘤細(xì)胞的增殖和周期變化, 促進(jìn)腫瘤細(xì)胞轉(zhuǎn)化, 并且通過MAPKK信號(hào)通路參與調(diào)控細(xì)胞DNA損傷修復(fù). |
| 產(chǎn)品圖片 |
Sample:
Bone (Mouse) Lysate at 40 ug
Primary: Anti- PBK/TOPK Dye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 36 kD
Sample:
Bone (Mouse) Lysate at 40 ug
Primary: Anti-PBK’TOPK (bs-21872R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 36 kD
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