| 產(chǎn)品編號(hào) | bs-48007P |
| 英文名稱 | Recombinant human IL-23 protein (Active, HEK293) |
| 中文名稱 | 重組人白介素23 (活性的, Tag free) |
| 別 名 | rhIL-23; IL 23; IL 23A; IL23P19; Interleukin 23 alpha subunit p19; JKA3 induced upon T cell activation; P19; SGRF; IL-23 subunit alpha; IL-23-A; IL-23p19; IL23; Il23a; IL23A_HUMAN; Interleukin 23 p19 subunit; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T cell activation; MGC79388; P19. ;Recombinant human IL-23 protein (Active, HEK293) 人白介素23 重組蛋白; 人白細(xì)胞介素23 ; 重組人白介素23; |
| 理論分子量 | 55 kDa |
| 檢測(cè)分子量 | 60 |
| 性 狀 | Lyophilized |
| 濃 度 | ＞0.5 mg/ml |
| 物 種 | Human |
| 序 列 | 23-189/189 |
| 純 度 | >95% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | <0.5 EU/μg as determined by LAL. |
| 表達(dá)系統(tǒng) | HEK293 cell |
| 活性 | Yes |
| 標(biāo)簽 | Tag free |
| 緩 沖 液 | Lyophilized from 0.22um filtered solution in PBS (pH7.4) with 5mM DTT. Normally 5% trehalose is added as protectant before Lyophilization. |
| 保存條件 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -80℃ under sterile conditions after r |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
IL-23 is a heterodimeric cytokine composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T cells and promotes production of proinflammatory cytokines, such as IFNγ and IL-17. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This recombinant human IL-23 is produced by human cells.(Tag free) Biological activity: The activity was measured by its ability to induce the IL-17 expression in murine splenocytes. Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 95% as determined by non reduced and reduced SDS-PAGE.
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