| 產(chǎn)品編號(hào) | D58015 |
| 英文名稱(chēng) | Taletrectinib free base |
| 中文名稱(chēng) | 他雷替尼游離堿 |
| 別 名 | DS-6051b free base; AB-106freebase; IBI-344 free base |
| CAS | 1505514-27-1 |
| 理論分子量 | 405.47 kDa |
| 檢測(cè)分子量 | |
| 保存條件 | Powder: -20℃ for 3 years | In solvent: -80℃ for 1 year |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Taletrectinib free base is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also inhibited ROS1 G2032R and other Crizotinib-resistant ROS1 mutations. |
