| 產(chǎn)品編號 | D61958 |
| 英文名稱 | PF-3450074 |
| 中文名稱 | |
| 別 名 | PF-74 |
| CAS | 1352879-65-2 |
| 理論分子量 | 425.52218 kDa |
| 檢測分子量 | |
| 保存條件 | -20℃ |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153 |
