| 產(chǎn)品編號 | D61986 |
| 英文名稱 | SAR-020106 |
| 中文名稱 | |
| CAS | 1184843-57-9 |
| 理論分子量 | 382.84676 kDa |
| 檢測分子量 | |
| 保存條件 | -20℃ |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents |
