| 產(chǎn)品編號(hào) | D61992 |
| 英文名稱 | AG-494 |
| 中文名稱 | |
| 別 名 | AG 494; Tyrphostin AG-494; Tyrphostin B48 |
| CAS | 133550-35-3 |
| 理論分子量 | 282.29 kDa |
| 檢測(cè)分子量 | |
| 保存條件 | 2-8℃ |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis |
