| 產(chǎn)品編號 | D62031 |
| 英文名稱 | BAY 61-3606 |
| 中文名稱 | |
| 別 名 | Syk inhibitor IV |
| CAS | 732983-37-8 |
| 理論分子量 | 390.3953 kDa |
| 檢測分子量 | |
| 保存條件 | -20℃ |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells |
