| 產(chǎn)品編號 | D62119 |
| 英文名稱 | Darusentan |
| 中文名稱 | 達(dá)盧生坦 |
| 別 名 | Lu-135252 |
| CAS | 171714-84-4 |
| 理論分子量 | 410.424 kDa |
| 檢測分子量 | |
| 保存條件 | -20℃ |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM |
