| 產(chǎn)品編號(hào) | bsm-63298R |
| 英文名稱 | phospho-Beta Catenin (T41/S45) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化β 連環(huán)素蛋白重組兔單抗 |
| 別 名 | CTNB1_HUMAN; Catenin beta-1; catenin beta 1; CTNNB1; Catenin beta; Beta-catenin; CTNNB; OK/SW-cl.35; PRO2286; EVR7; MRD19; NEDSDV; armadillo; βcatenin; β catenin; β-catenin; |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 1B5 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 85 kDa |
| 檢測(cè)分子量 | 92 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human beta Catenin around the phosphorylation site of T41/S45 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. SWISS: P35222 Gene ID: 1499 細(xì)胞粘附蛋白（Call Adhesion Protein） β連環(huán)素蛋白β-catenin是一種多功能的蛋白質(zhì)，能鏈接E-\N-,鈣粘附分子具有參與細(xì)胞粘附和介導(dǎo)信號(hào)轉(zhuǎn)導(dǎo)的雙重功能，并與腫瘤的發(fā)生發(fā)展及浸潤(rùn)密切相關(guān)。 在正常個(gè)體中，β-catenin和鈣黏蛋白形成復(fù)合體，介導(dǎo)同型細(xì)胞的粘附，維持細(xì)胞的穩(wěn)定；同時(shí)，β-catenin作為Wnt/β-catenin信號(hào)通路的關(guān)鍵成員在介導(dǎo)信號(hào)轉(zhuǎn)導(dǎo)過程中調(diào)控細(xì)胞的增殖和凋亡。 在惡性腫瘤中，β-catenin的表達(dá)呈現(xiàn)明顯的異質(zhì)性，促使細(xì)胞異常增殖，還可使細(xì)胞之 |
