| 產(chǎn)品編號 | IHC0496H |
| 英文名稱 | Human STK3 Ready-To-Use IHC Kit |
| 中文名稱 | 人蛋白激酶MST2即用型免疫組化試劑盒 |
| 別 名 | 0610042I06Rik; KRS1; Mess1; MST; MST2; Mst3; Ste20; STK3; MST 2; STE20 like kinase MST2 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. SWISS: Q13188 Gene ID: 6788 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human placenta tissue slide using IHC0496H (Human STK3 IHC Kit).
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0496H (Human STK3 IHC Kit).
Immunohistochemical analysis of paraffin embedded human breast cancer tissue slide using IHC0496H (Human STK3 IHC Kit).
|
