產(chǎn)品編號(hào) | bs-6175R-APC |
英文名稱 | Rabbit Anti-RAB5/APC Conjugated antibody |
中文名稱 | APC標(biāo)記的ras癌基因家族Rab5蛋白抗體 |
別 名 | RAB 5; RAB 5A; RAB5A; RAB5A member RAS oncogene family; RAB5A_HUMAN; RAS associated protein RAB5A; Ras related protein Rab 5A; Ras-related protein Rab-5A. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白 |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 24kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human RAB5. |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Rab5-related subfamily. This subfamily includes Rab5 and Rab22 of mammals, Ypt51/Ypt52/Ypt53 of yeast, and RabF of plants. The members of this subfamily are involved in endocytosis and endocytic-sorting pathways. In mammals, Rab5 GTPases localize to early endosomes and regulate fusion of clathrin-coated vesicles to early endosomes and fusion between early endosomes. In yeast, Ypt51p family members similarly regulate membrane trafficking through prevacuolar compartments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Subunit: Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Similarity: Belongs to the small GTPase superfamily. Rab family. Database links: Entrez Gene: 5868 Human Entrez Gene: 271457 Mouse Omim: 179512 Human SwissProt: P20339 Human SwissProt: Q9CQD1 Mouse Unigene: 475663 Human Unigene: 329123 Mouse Unigene: 44477 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 77777少妇AAAAA片毛片 | 岳胥乱一区二区三区视频 | 国产又粗又猛又爽又黄的视频先 | 91人妻一区二区三区蜜臀 | 亲孑伦视频一区二区三区 | 无码中文字幕视频一区二区三区 | 色噜噜狠狠一区二区三区牛牛影视 | 成年免费视频黄网站在线观看 | 亚洲一区二区三区在线观 | 中文字幕乱码在线观看 | 欧美精品一区二区少妇免费A片 | 黄色视频免费观看无码 | 五十路老熟妇一区二区三区 | 无码人妻丰满熟妇啪啪欧美 | 91麻豆精品国产 | 亚洲无码在线免费观看 | 国产精品国产三级国产 | 波多野结衣乳巨码无在线观看 | 国产又大又硬又粗无遮挡 | …老熟女高潮一区二区三区国产9… | 精品乱码一区内射人妻无码 | 综合久久国产九一剧情麻豆 | 国产精品白丝jk喷白浆软件 | 中文字幕熟女人妻av一区二区三区 | 国产毛片精品区色欲黄A片 州产精无码久久久久久高潮 | 国产精品高清无码 | 国产熟妇毛片一级A片爽动漫 | 日本成熟人妻理伦无码新片 | 国产精品一区二区久久末发育娇小 | 亚洲成人精品女人久久久 | 国产精品WWW久久久久久 | 国产福利姬喷白浆流水 | 影音先锋AV无码男人专区 | 在线观看免费视频麻豆 | 麻豆性色无码精品一区二区 | 少妇全程高潮喷水WWW久久 | 国产亲子伦A片免费看 | 精品人妻无码中文字幕在线 | 韩国无码成人片在线观看 | 女人腿张开让男人桶爽肌肌 |