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Rabbit Anti-gamma Synuclein/BF594 Conjugated antibody (bs-0622R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-0622R-BF594
英文名稱 Rabbit Anti-gamma Synuclein/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的核突觸蛋白-γ抗體
別    名 BCSG1; gamma-Synuclein; Breast cancer specific gene 1 protein; Breast cancer specific protein 1; Breast cancer-specific gene 1 protein; Gamma synuclein; Persyn; PRSN; SNCG; SR; Synoretin; Synuclein gamma; SYUG_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Dog, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13.5kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human gamma Synuclein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The synculein family consists of 3 highly conserved proteins of between 120 and 140 amino acids that share substantial sequence homology. Each has a series of loosely repeated motifs throughout the first 93 amino acids and an acid region toward the C terminal. The proteins are heat stable and relatively soluble. Three synucleins have been identified and termed alpha, beta and gamma synuclein and are located in the neuronal cytosol and enriched in presynaptic terminals,gamma synuclein is also expressed in many other non-neuronal tissues. Although the precise function of the synucleins are unknown a role in membrane plasticity has been suggested. The synucleins have been implicated in a number of diseases. It has been reported that in breast cancer increased expression of gamma synuclein correlates with disease progression.

Function:
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.

Subunit:
May be a centrosome-associated protein.

Subcellular Location:
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.

Tissue Specificity:
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Post-translational modifications:
Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.

Similarity:
Belongs to the synuclein family.

Database links:

Entrez Gene: 6623 Human

Entrez Gene: 20618 Mouse

Entrez Gene: 64347 Rat

Omim: 602998 Human

SwissProt: O76070 Human

SwissProt: Q9Z0F7 Mouse

SwissProt: Q63544 Rat

Unigene: 349470 Human

Unigene: 282800 Mouse

Unigene: 2883 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)生物學(xué)相關(guān)蛋白(Neurobiology)

SNCG(gamma-Synuclein)蛋白在各種癌癥組織中呈廣范表達(dá),存在較高的異常表達(dá)率,SNCG蛋白表達(dá)與癌癥分期有關(guān),I期表達(dá)率低,Ⅱ~Ⅳ期表達(dá)率高。尤其重要的是:經(jīng)研究發(fā)現(xiàn)無論何種原發(fā)性腫瘤,SNCG蛋白的出現(xiàn)與癌癥遠(yuǎn)處轉(zhuǎn)移都有很高的關(guān)聯(lián)性。
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