| 產(chǎn)品編號 | bs-1384R-RBITC |
| 英文名稱 | Rabbit Anti-APG4B/RBITC Conjugated antibody |
| 中文名稱 | 羅丹明（RBITC）標(biāo)記的自噬相關(guān)蛋白4B抗體 |
| 別 名 | APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; MGC1353br. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Dog, Cow, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APG4B |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Subcellular Location: Cytoplasm (Probable). Tissue Specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Similarity: Belongs to the peptidase C54 family. Database links: Entrez Gene: 23192 Human Entrez Gene: 66615 Mouse Omim: 611338 Human SwissProt: Q9Y4P1 Human SwissProt: Q8BGE6 Mouse Unigene: 283610 Human Unigene: 29087 Mouse Unigene: 163086 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 細胞自噬（Autophagy）是一種非凋亡性的程序性細胞死亡即自噬性程序性細胞死亡，進化過程中高度保守，清除降解細胞內(nèi)受損傷的細胞結(jié)構(gòu)、衰老的細胞器、以及不再需要的生物大分子等，在細胞的生長、發(fā)育和疾病發(fā)生中起著重要的作用。細胞自噬是一個高效調(diào)控過程，特異性激酶和鳥嘌呤核苷酸磷酸酶（GTPases）在調(diào)節(jié)自噬通道活性中起著關(guān)鍵作用. |
