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Rabbit Anti-ITK/Cy7 Conjugated antibody (bs-2784R-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2784R-Cy7
英文名稱 Rabbit Anti-ITK/Cy7 Conjugated antibody
中文名稱 Cy7標記的IL-2誘導(dǎo)型T細胞激酶抗體
別    名 EMT; Homolog of mouse T cell itk/tsk; IL2 inducible T cell kinase; Kinase EMT; LYK; MGC126257; MGC126258; PSCTK 2; PSCTK2; T cell specific kinase; TSK; Tyrosine protein kinase; Tyrosine protein kinase ITK/TSK; Tyrosine protein kinase Lyk; ITK_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ITK/PSCTK2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Function:
Plays a role in T-cell proliferation and differentiation.

Subcellular Location:
Cell membrane. Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells.

Tissue Specificity:
T-cell lines and natural killer cell lines.

DISEASE:
Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1) [MIM:613011]. LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Contains 1 Btk-type zinc finger.
Contains 1 PH domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 3702 Human

Entrez Gene: 16428 Mouse

Entrez Gene: 363577 Rat

Omim: 186973 Human

SwissProt: Q08881 Human

SwissProt: Q03526 Mouse

Unigene: 558348 Human

Unigene: 339927 Mouse

Unigene: 145244 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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