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Rabbit Anti-TNFAIP3/APC Conjugated antibody (bs-2803R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2803R-APC
英文名稱 Rabbit Anti-TNFAIP3/APC Conjugated antibody
中文名稱 APC標(biāo)記的腫瘤壞死因子α誘導(dǎo)蛋白3抗體
別    名 Zinc finger protein A20; A20; TNFA1P2; TNFAIP 3; Tnfip 3; Tnfip3; Tumor necrosis factor alpha induced protein 3; Tumor necrosis factor induced protein 3; Tumor necrosis factor inducible protein A20; MGC104522; MGC138687; MGC138688; OTU domain containing protein 7C; OTUD7C; Putative DNA binding protein A20.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  信號轉(zhuǎn)導(dǎo)  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TNFAIP3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases

Function:
TNFAIP3 interacts with NAF1 and inhibits TNF induced NF kappa B dependent gene expression by interfering with a RIP or TRAF2 mediated transactivation signal. It inhibits programmed cell death, has a role in the function of the lymphoid system, and may contribute to the in vivo effects of TNF.

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Belongs to the peptidase C64 family.
Contains 7 A20-type zinc fingers.
Contains 1 OTU domain.

Database links:

Entrez Gene: 7128 Human

Entrez Gene: 21929 Mouse

Omim: 191163 Human

SwissProt: P21580 Human

SwissProt: Q60769 Mouse

Unigene: 211600 Human

Unigene: 116683 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

TNFAIP3是一種泛素修飾酶,是機體重要的炎癥反應(yīng)負(fù)性調(diào)節(jié)因子,也是NF-κB的負(fù)調(diào)節(jié)蛋白。TNFAIP3蛋白與很多變態(tài)反應(yīng)疾病的病理生理演變相關(guān)聯(lián),如:包括類風(fēng)濕關(guān)節(jié)炎、冠狀動脈疾病、銀屑病、腹腔疾病、I型糖尿病、炎癥性腸炎和系統(tǒng)性紅斑狼瘡等。
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