產(chǎn)品編號 | bs-2993R-APC |
英文名稱 | Rabbit Anti-IRF3/APC Conjugated antibody |
中文名稱 | APC標(biāo)記的干擾素調(diào)節(jié)因子3 |
別 名 | Interferon regulatory factor 3; IRF-3; IRF 3; IRF3_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 免疫學(xué) 細胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 47kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human IRF3 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. Subunit: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1 (via C-terminus); this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5. Subcellular Location: Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Tissue Specificity: Expressed constitutively in a variety of tissues. Post-translational modifications: Constitutively phosphorylated on many serines residues. C-terminal serine/threonine cluster is phosphorylated in response of induction by IKBKE and TBK1. Ser-385 and Ser-386 may be specifically phosphorylated in response to induction. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection. Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3. Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation. ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation. Similarity: Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain. Database links: Entrez Gene: 3661 Human Entrez Gene: 54131 Mouse Omim: 603734 Human SwissProt: Q14653 Human SwissProt: P70671 Mouse Unigene: 289052 Human Unigene: 75254 Human Unigene: 3960 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 干擾素調(diào)節(jié)因子家族是一大類對干擾素起調(diào)控作用的轉(zhuǎn)錄因子的統(tǒng)稱。 一般認為干擾素調(diào)節(jié)因子(IRF)通過調(diào)節(jié)干擾素的表達而行使其抗病毒、應(yīng)激、免疫調(diào)節(jié)功能。近年來,研究人員發(fā)現(xiàn)IRF在細胞凋亡、細胞周期、細胞分化、腫瘤發(fā)生中也起著重要的調(diào)節(jié)作用。 |
| 欧美熟妇大屁股BBBBBB | 欧性美掹交ⅩⅩⅩXXX | 精品秘 无码一区二区三 | 中文字幕一区二区三区被窝 | 国产精品久久久久久五月天加勒比 | 日韩护士一级A片无码 | 久久午夜麻豆免费剧场 | 日本五十路有码中文中出 | 日本少妇BBw搡BBBB槡BBBB 中国大学生老师性服务黄色片一区二区 | 亚洲男人天堂av | 免费无码婬A片在线视频夜场 | 91人妻无码一区二区三区 | 国产毛毛AAAAAAA做受 | 无码人妻精品一区二区二秋霞影院 | 最好看的2019在线观看电视剧 | 我想看毛片黄色三级片 | 免费观看理论片A片高清免费观看 | 国产色情无码A片爆乳直播 91人妻无码成人精品一区 | 国产精品久久久久久久久爆乳污 | 免费观看婬乱男女婬视频 | 午夜人妻无码精品视频 | 手机在线不卡无码操三八 | 国产一级做a爱免费高潮小说 | 一级毛片久久久久久久女人18 | 免费看一级A片人与拘 | 国产精品久久久午夜夜伦鲁鲁 | 亚洲 小说区 图片区 | 在线免费观看黄色视频网站 | 欧美xxx黑人xxx | 国产人妻精品一区二区 | 中文字幕日韩精品人妻 | 久久久国产精品一区二区白洁老师 | 四川少妇BBBBBB爽爽电影 | 免费看的黄色视频网站 | 欧美性XXX黑人XYX | 污污网站大全入口在线观看 | 91麻豆秘秘 密入口蜜柚 | 真实的国产乱XX熟妇免费 | 精品人妻一区二区三区潮喷在线 | 在线观看免费黄色视频网站 |