强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
免费无码人婬片AAAA公交车,日本三级吃奶头添泬无码视频网站 ,亚洲AV无码乱码A片无码沈樵
Rabbit Anti-Phospho-TORC2 (Ser171)/Cy5 Conjugated antibody (bs-3415R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3415R-Cy5
英文名稱 Rabbit Anti-Phospho-TORC2 (Ser171)/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的磷酸化CREB轉(zhuǎn)錄共激活因子TORC2抗體
別    名 TORC2 (phospho S171); TORC2 (phospho Ser171); p-TORC2 (Ser171); CREB regulated transcription coactivator 2; CRTC2; RP11-422P24.6; TORC-2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein; Transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2; Transducer of regulated CREB protein 2; CRTC2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].

Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Subunit:
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Interacts with PPP3CA/calcineurin alpha, SIK2 and 14-3-3 proteins, YWHAB and YWHAG. Interaction with the human T-cell leukemia virus type 1 (HTLV-1) Tax protein is essential for optimal transcription activation by Tax. Interaction with RFWD2/COP1 mediates nuclear export and degradation of CRTC2.

Subcellular Location:
Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.

Tissue Specificity:
Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.

Post-translational modifications:
Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1. Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it. Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx. Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm.

Similarity:
Belongs to the TORC family.

Database links:

Entrez Gene: 200186 Human

Entrez Gene: 74343 Mouse

Entrez Gene: 310615 Rat

Omim: 608972 Human

SwissProt: Q53ET0 Human

SwissProt: Q3U182 Mouse

SwissProt: Q3LRZ1 Rat

Unigene: 406392 Human

Unigene: 35627 Mouse

Unigene: 13599 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CREB轉(zhuǎn)錄共激活因子TORC2又稱葡萄糖關(guān)鍵調(diào)控蛋白TORC-2。
版權(quán)所有 2004-2026 www.nmgps.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
免费观看一级毛一片 | 亚洲高清视频在线 | 国产伪娘系列曦曦白丝露出 | 中文字幕一二三区 | 无码人妻一区二区三区免费京洛会 | 亚洲 无码 在线 播放 | 双飞两女爽翻天视频 | 国产农村一级特黄妇女A片一 | 无码人妻精品一区二区蜜桃网站 | 人妻白浆天堂狠狠夜夜 | 精品少妇一区二区三区 | 3D动漫精选啪啪一期二期三期 | 日本中文字幕在线看 | 亚洲无码免费在线观看 | 福利姬视频在线www 成人午夜色情无码精品 | 无码狂躁久久久久久老妇肾复康 | 国产又粗又大免费视频 | 亚洲AV无码秘 蜜桃 一级A片猛交BBBB | 成人免费黃色欧美大片 | 欧美群交性XXXX狂野 | 蜜桃av无码一区二区三区 | 久久成人影视白浆潮喷视频在线观看 | 东北少妇不戴套对白第一次 | 91探花国产综合在线精品 | 高潮毛片无遮挡免费高清古代的 | 四虎成人影视8848亚洲 | 免费码婬片AAAA片视频软件 | 久久夜色撩人国产综合AV | 中文幕无线码中文字蜜桃 | 国产无套内射普通话对白精品 | 人人妻人人澡人人爽久久av | 色噜噜人妻av中文字幕 | 91拍真实国产伦偷精品 | 欧美性猛交XXXXX水多 | 国产一级A片免费视频翻白浆 | 影音先锋AV无码水多多 | 夏晴子福利视频在线免费 | 国产高清无码视频 | 国产寡妇婬乱精品视频 | 亚洲成人精品女人久久久 | 国产成人无码久久久久毛片朴信惠 |