强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久精品秘 一区二区国产,免费一级婬A片AAA毛片古女,色综合久久天天综合网
Rabbit Anti-Phospho-YB1(Ser102)/PE Conjugated antibody (bs-3477R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3477R-PE
英文名稱 Rabbit Anti-Phospho-YB1(Ser102)/PE Conjugated antibody
中文名稱 PE標(biāo)記的磷酸化核酸酶敏感元件結(jié)合蛋白1抗體
別    名 Y box-binding protein1; nuclease sensitive element binding protein 1; YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1; MGC104858; MGC110976; MGC117250; YBX1; CCAAT binding transcription factor I subunit A; DNA binding protein B; major histocompatibility complex, class II, Y box-binding protein I; CBF-A; EFI-A; Enhancer factor I subunit A; EFI-A; p50; Q15905; YBOX1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human YB1 around the phosphorylation site of Ser102
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The Y-box binding protein 1(YB1)is a pluripotent DNA/RNA-binding factor which regulates gene expression through transcription and translation. YB1 has been shown to be a marker of tumour aggressiveness and belongs to the cold-shock domain family.

Function:
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.
The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.

Subunit:
Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts with IGF2BP1 and RBBP6. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, MBNL1, SFRS9, ALYREF/THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP. Interacts (via C-terminus) with APEX1 (via N-terminus); the interaction is increased with APEX1 acetylated at 'Lys-6' and 'Lys-7'. Interacts with EIF2C1 and EIF2C2.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.

Post-translational modifications:
Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability.
In the absence of phosphorylation the protein is retained in the cytoplasm.br
Similarity:
Contains 1 CSD (cold-shock) domain.

Database links:

Entrez Gene: 4904 Human

Entrez Gene: 22608 Mouse

Entrez Gene: 500538 Rat

Omim: 154030 Human

SwissProt: P67809 Human

SwissProt: P62960 Mouse

SwissProt: P62961 Rat

Unigene: 473583 Human

Unigene: 258204 Mouse

Unigene: 110976 Rat

Unigene: 194909 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.nmgps.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
四川农村少妇A片免费看 | 成人A片99产无码蜜柚在线 | 国产一级一片免费播放放a 国产精品嫩草AV城中村 | 蜜桃传媒女同三级AV一区 | 精品无码人妻口爆日本欧美 | 日韩电影免费在线观看 | 凹凸人妻视频一二三区视频 | 国产又粗又大又爽又黄 | 日本熟女黄色视频下载 | 日韩精品偷窥自拍 | 人人妻人人澡欧美91精品 | 伊人色综合久久天天五月网 | 国产迷奷高潮A片XXXX-百度 | 久久精品人妻一区二区蜜桃 | 国产精品无码一区二区毛片视频 | 无码人妻精品一区二区三区蜜臀百度 | 国产又黄又粗又猛又爽 | 极品熟女人妻20p白浆出来了 | 欧美精品无码一区二区成人片 | 91精品国产综合久久蜜臀使用方法 | 亚洲免费av在线免费看 | 中文字幕在线免费观看视频 | 人妻丰满熟妇Ⅴ无码区A片水多多 | 全光裸体一级A片免费看 | 国产精品无码乱码高潮 | 99国内揄拍国内精品人妻免费 | 搡老女人老妇女aaa一区麻豆 | 寡妇愉情理伦片高潮 | 伊人精品A片一区二区三区 中文乱码字幕人妻熟女人妻 | 丰满人妻的婬乱生活2 | AAA级无码肉欲免费看 | 虎色视频成人版免费 | 白洁老师国产麻豆片 | 国产高清无码不卡黄色电影 | 自慰 免费网站com | 国产色欲婬乱免费视频高潮 | 亚洲 丝袜 麻豆 国产 | 一级婬片A片试看45分钟 | 国产最大最粗无套内谢 | 亚洲一级视频在线观看 | 99久久婷婷国产精品综合 |