| 產(chǎn)品編號(hào) | bs-3673R-AP |
| 英文名稱 | Rabbit Anti-DIO2/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的脫碘酶2抗體 |
| 別 名 | 5DII; D2; Deiodinase, iodothyronine, type II; DIOII; ITDI2; SelY; Thyroxine deiodinase, type II; TXDI2; Type 2 DI; Type II 5' deiodinase; Type II iodothyronine deiodinase. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 生長因子和激素 內(nèi)分泌病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DIO2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: DIO2 belongs to the iodothyronine deiodinase family and is responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). It is essential for providing the brain with appropriate levels of T3 during the critical period of development. DIO2 is expressed in heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain. There are two named isoforms. Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. Subunit: Interacts with USP20 and USP33. Interacts with MARCH6. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Tissue Specificity: Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain. Post-translational modifications: Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33. Similarity: Belongs to the iodothyronine deiodinase family. Database links: Entrez Gene: 1734 Human Entrez Gene: 13371 Mouse Omim: 601413 Human SwissProt: Q92813 Human SwissProt: Q9Z1Y9 Mouse Unigene: 202354 Human Unigene: 21389 Mouse Unigene: 408815 Mouse Unigene: 88380 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脫碘酶2泛稱Ⅱ型碘甲腺氨酸脫碘酶脫碘，是調(diào)節(jié)甲狀腺激素生物活性的特別方式。脫碘酶可加速T4轉(zhuǎn)化為T3，引起甲狀腺激素及生長激素分泌減少，影響一些機(jī)體生物學(xué)的改變。 DIO2主要表達(dá)在中樞神經(jīng)系統(tǒng)、垂體前葉腺體、棕色脂肪組織和胎盤內(nèi)。其他組織中也有一定量的分布：心肌和骨胳肌、肝、腎、中樞神經(jīng)系統(tǒng)、 腦，皮膚，胎盤等。 |
