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Rabbit Anti-UBF1/Cy7 Conjugated antibody (bs-2362R-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2362R-Cy7
英文名稱 Rabbit Anti-UBF1/Cy7 Conjugated antibody
中文名稱 Cy7標記的RNA聚合酶I抗體
別    名 UBF; NOR 90; Nucleolar transcription factor 1; UBF 1; UBF-1; UBF; UBTF; Autoantigen NOR-90; Upstream-binding factor 1; Upstream binding factor 1; upstream binding transcription factor, RNA polymerase I; UBF1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  染色質和核信號  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Cow, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 89kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBF1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

Function:
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.

Subcellular Location:
Nucleus

Post-translational modifications:
Phosphorylated and activated by PIK3CA.

Similarity:
Contains 6 HMG box DNA-binding domains.

Database links:

Entrez Gene: 7343 Human

Entrez Gene: 21429 Mouse

Entrez Gene: 25574 Rat

Omim: 600673 Human

SwissProt: P17480 Human

SwissProt: P25976 Mouse

SwissProt: P25977 Rat

Unigene: 89781 Human

Unigene: 2845 Mouse

Unigene: 22469 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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