| 產(chǎn)品編號(hào) | bs-1183R-BF488 |
| 英文名稱(chēng) | Rabbit Anti-IL-17/BF488 Conjugated antibody |
| 中文名稱(chēng) | BF488標(biāo)記的白介素-17抗體 |
| 別 名 | Interleukin-17; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL17A; IL-17A; Interleukin 17; Interleukin 17A; Interleukin17; Interleukin17A. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL-17 (85-150aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: IL17, also known as CTLA8, is a T cell derived hematopoietic cytokine. It was originally cloned from a T cell hybridoma produced by fusion of a mouse cytotoxic T cell clone and a rat T lymphoma. IL17 exhibits multiple biological activities on a variety of cells including: the induction of IL6, IL8 and GCSF production in fibroblasts; the enhancement of surface expression of ICAM 1 in fibroblasts; activation of NF kappaB and costimulation of T cell proliferation. IL17 is an approximately 16 kDa polypeptide of 136 amino acids. The precursor form of IL17 consists of 155 amino acids. To generate the mature IL17 (136 amino acids), the precursor cleaves a 19 amino acid signal peptide. Human IL17 shows approximately 62.5% amino acid homology to mouse IL17 and 58% amino acid homology to rat IL17. Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Restricted to a subset of activated T-cells. Post-translational modifications: Found both in glycosylated and nonglycosylated forms. Similarity: Belongs to the IL-17 family. Database links: Entrez Gene: 3605 Human Entrez Gene: 16171 Mouse Omim: 603149 Human SwissProt: Q16552 Human SwissProt: Q62386 Mouse Unigene: 41724 Human Unigene: 5419 Mouse Unigene: 218513 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 白細(xì)胞介素17（IL-17A）是一種來(lái)源于活化T淋巴細(xì)胞的細(xì)胞因子,具有較廣泛的生物學(xué)活性,它能夠通過(guò)誘導(dǎo)基質(zhì)細(xì)胞產(chǎn)生前炎性細(xì)胞因子和造血細(xì)胞因子參與機(jī)體免疫調(diào)節(jié)及部分炎癥反應(yīng)，因此白細(xì)胞介素IL-17A可能是某些疾病發(fā)生發(fā)展的重要因素之一。Interleukin-17 原稱(chēng)CTLA-8, 是T細(xì)胞表達(dá)的多肽，參與造血干系統(tǒng)的調(diào)節(jié)，已經(jīng)顯示IL-17促進(jìn)纖維母細(xì)胞產(chǎn)生IL-6，IL-8和G-CSF。 |
