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Rabbit Anti-IQGAP1/BF350 Conjugated antibody (bs-1109R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1109R-BF350
英文名稱 Rabbit Anti-IQGAP1/BF350 Conjugated antibody
中文名稱 BF350標記的支架蛋白抗體
別    名 IQ motif containing GTPase activating protein 1; KIAA0051; p195; Ras GTPase activating like protein 1; IQGA1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 189kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IQGAP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
IQGAP1 is a widely expressed protein than interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology. It binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.

Function:
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.

Subunit:
Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.

Post-translational modifications:
Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 4 IQ domains.
Contains 1 Ras-GAP domain.
Contains 1 WW domain.

Database links:

Entrez Gene: 8826 Human

Entrez Gene: 29875 Mouse

Entrez Gene: 361598 Rat

Omim: 603379 Human

SwissProt: P46940 Human

SwissProt: Q9JKF1 Mouse

Unigene: 430551 Human

Unigene: 207619 Mouse

Unigene: 106939 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

支架蛋白IQGAP1與許多重要的細胞活動緊密相關(guān),如黏附和遷移。研究發(fā)現(xiàn)在損傷修復、組織發(fā)展、腫瘤轉(zhuǎn)移等過程中,IQGAP1的表達和功能有明顯改變。同時作為Rh.GTPase信號的主要效應因子,IQGAP1能傳遞細胞外信號至黏附素復合體、細胞骨架以及細胞核。通過上述信號通路,IQ-GAP1協(xié)助細胞完成一系列重要生理病理活動。
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