强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
搡BBB,搡BBBB,搡BBBB,国产一级一片免费播放放a
Rabbit Anti-SLC12A3/BF488 Conjugated antibody (bs-7694R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-7694R-BF488
英文名稱 Rabbit Anti-SLC12A3/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的鈉氯離子轉(zhuǎn)運蛋白抗體
別    名 Na Cl symporter; Na-Cl symporter; NaCl electroneutral thiazide sensitive cotransporter; NCCT; S12A3_HUMAN; slc12a3; Solute carrier family 12 (sodium/chloride transporters) member 3; Solute carrier family 12 member 3; Thiazide sensitive Na Cl cotransporter; Thiazide sensitive sodium chloride cotransporter; Thiazide-sensitive sodium-chloride cotransporter; TSC.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  通道蛋白  轉(zhuǎn)運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 113kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC12A3/NCCT
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome.

Function:
Electrically silent transporter system. Mediates sodium and chloride reabsorption.

Subunit:
Interacts with KLHL3.

Subcellular Location:
Membrane.

Tissue Specificity:
Predominant in kidney.

Post-translational modifications:
Ubiquitinated; ubiquitination is essential for regulation of endocytosis (By similarity). May be ubiquitinated by the BCR(KLHL3) complex.

DISEASE:
Defects in SLC12A3 are the cause of Gitelman syndrome (GS). GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.

Similarity:
Belongs to the SLC12A transporter family.

Database links:

Entrez Gene: 6559 Human

Entrez Gene: 20497 Mouse

Entrez Gene: 54300 Rat

Omim: 600968 Human

SwissProt: P55017 Human

SwissProt: P59158 Mouse

SwissProt: P55018 Rat

Unigene: 669115 Human

Unigene: 25804 Mouse

Unigene: 10467 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.nmgps.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产乡下妇女做爰毛片村计 | 国精产品AV自偷自偷综合 | 黑人狂躁日本少妇在线小说 | 成人免费婬片AA视频免费 | 欧美成人dvd在线视频 | 日韩精品无码人妻第一页 | 人人妻人人操人人操 | 欧美午夜精品久久久久久浪潮 | 国产99久久久久久久久 | 蜜桃臀aⅴ精品一区二区三区 | 中文字幕日韩视频在线 | 少妇丰满的肉体A片视频 | 高清无码一区二区三区在线视频 | 亚洲嫩模视频免费观看 | 人妻波多野结衣三A片 | 成人午夜电影在线观看 | 日本中文字幕爱丝袜 | 国产无码免费视频 | 亚洲精品无码成人片久久-涡桑剁 | 欧美性调教网站视频 | 亚欧无码视频一区二区三区 | 色秘 乱码一区二区三在线看 | 国产一级毛片视频 | 特大黑人巨人吊XXXX | 精品成人A片久久久久久久久 | 国产裸体免费无遮挡 | 免费看污黄网站 7 8在线观看 | 一级特黄aaaaaa片大水 | 91麻豆精品国产人妻一区二区三区 | 精品少妇人妻av无码中文字幕 | 91在线无码精品秘 蜜桃 | 国产又粗又猛又爽 | 欧美在线视频免费观看 | 国产91 丝袜在线播放 | 精品A片成人国产一区 | 水蜜桃精品在线观看 | 亚洲无码久久久久 | 久久精品秘 一区二区国产 亚洲精品成人A片动漫 | 999人妻少妇精品视频 | 国产免费色情网站入口大全 | 蜜桃秘 无码一区二区三区 91久久人澡人人添人人爽 |