產(chǎn)品編號(hào) | bs-8443R-Bio |
英文名稱 | Rabbit Anti-Lin28/Biotin Conjugated antibody |
中文名稱 | 生物素標(biāo)記的RNA結(jié)合蛋白LIN28抗體 |
別 名 | Lin 28; Lin28A; Lin 28 homolog (C. elegans); Lin 28 homolog A; Lin 28 homolog; Lin-28;y Lin-28 homolog (C. elegans); Lin-28 homolog A; Lin-28A; Lin28; Lin28a; LN28A_HUMAN; Protein lin-28 homolog A; RNA binding protein lin 28; RNA binding protein lin-28; Tex17; ZCCHC1; Zinc finger CCHC domain containing 1; Zinc finger CCHC domain containing protein 1; Zinc finger CCHC domain-containing protein 1; AL024421; CSDD1. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 干細(xì)胞 表觀遺傳學(xué) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 29kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Lin28 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II. Function: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Subunit: Monomer. During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent (By similarity). Interacts with ZCCHC11/TUT4. Subcellular Location: Cytoplasm. Nucleus > nucleolus. Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules. Tissue Specificity: Expressed in embryonic stem cells (ES cells), placenta and testis. Similarity: Belongs to the lin-28 family. Contains 2 CCHC-type zinc fingers. Contains 1 CSD (cold-shock) domain. Database links: Entrez Gene: 79727 Human Entrez Gene: 83557 Mouse Omim: 611043 Human SwissProt: Q9H9Z2 Human SwissProt: Q8K3Y3 Mouse Unigene: 86154 Human Unigene: 302567 Mouse Unigene: 147538 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 安徽妇女BBBWBBBwm | 国产又粗又黄又爽 | 国产AV一区二区三区 | 日韩精品人妻一区二区 | 无码A片全身按摩AⅤ | 黄红桃成人A片免费观看 | 91久久人澡人人添人人爽欧美 | 国产一级婬片A片AAA蜜臂 | 久久久精品三级久久久 | 福利视频一区二区 | 无码人妻精品秘 一区二区 免费在线观看黄色视频网站 | 精品火热分享久久一区二区 | 日本无码少妇内射视频 | 北条麻妃一区二区三区四区五区 | 熟女人妻aⅴ一区二区三区60路 | 调教丝袜在线观看91 | 人妻人人澡人人添人人爽国产一区 | 色诱大奶少妇在线看 | A片试看120分钟做受视频红杏 | 夜夜爽AV福利精品导航 | 国产永久免费裸体美女 | 国产一级婬片AAAAAA片车 | 国精产品久拍自产在线网站 | 亚洲无码视频在线观看 | 欧美BBBBBBBBBBBB精品 | 天天干天天干天天插天天爽 | 无码中文字幕视频在线观看 | 国产伦精品一区二区三区竹菊视频 | 特级BBBBBBBBB视频 | 蜜桃AV噜噜噜一区二区 | 粉嫩小泬无码无套在线观看 | 国产精品久久久久999 | 西西4444WWW大胆无视频双腿 | 国产色情aⅴ一级毛片黄 | 穿丝袜做爰高潮视频视频 | 亚洲AV成人片无码网站木瓜小说 | 又紧又大又粗又硬又长视频 | 日本理论片午伦夜理片更新时间 | 少妇高潮灌满白浆毛片免费看 | 国产精品久久久AV |