產(chǎn)品編號 | bs-0381R-BF647 |
英文名稱 | Rabbit Anti-Spectrin alpha chain, non-erythrocytic 1/BF647 Conjugated antibody |
中文名稱 | BF647標(biāo)記的血影蛋白A鏈非紅細(xì)胞型/收縮蛋白/Spectrin α抗體 |
別 名 | alpha-II spectrin; SPTN1_HUMAN; Alpha Fodrin; Spectrin-Alpha; SPEC; Spectrin, alpha, non-erythrocy tic 1 variant; Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit; SPTAN1; SPTA2; spectrin, non-erythroid alpha chain; alpha-fodrin; spectrin, non-erythroid alpha subunit; spectrin alpha chain, non-erythrocytic 1; EIEE5; NEAS; Spectrin α II; Spectrin α-II; Spectrin αII; Spectrin-α II. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 心血管 細(xì)胞生物 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 272kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Spectrin alpha chain, non-erythrocytic 1 (20-65aa) |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] Function: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Subunit: Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM and EMD. Interacts (via C-terminal spectrin repeats) with TRPC4. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. Post-translational modifications: Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. DISEASE: Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:613477]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia. Similarity: Belongs to the spectrin family. Contains 3 EF-hand domains. Contains 1 SH3 domain. Contains 23 spectrin repeats. Database links: Gene ID: 6709 Human SwissProt: Q13813 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血影蛋白(spectrin)又稱收縮蛋白,是紅細(xì)胞膜骨架的主要成份,參與了細(xì)胞骨架結(jié)構(gòu)的形成。但不是紅細(xì)胞膜蛋白的成份,約占膜提取蛋白的30%。血影蛋白屬是類似肌球蛋白的膜的外在性蛋白的一種。Spectrin α是膜里側(cè)結(jié)構(gòu)蛋白質(zhì)之一,除起支持雙層脂質(zhì)外,還有保持紅細(xì)胞外形的作用,Spectrin-α占里側(cè)結(jié)構(gòu)蛋白之60—70%。 |
| 激情小说 激情图片 | 成人无码特级视频在线观看 | 肥婆BBB搡BBBB搡搡搡 | 亚洲AV不卡无毒免费在线 | 日韩中文字幕电影在线观看 | 少妇婬片A级毛片贵妇 | 亚洲国产精品一区二区久久阿宾 | 污网站在线免费观看 | 国产高清在线观看 | 白咲碧绝顶高潮潮喷失禁 | 国产亲子乱弄免费视频 | 女人一级毛片免费看 | 蜜桃无码人妻丰满熟妇区五十路i | 免费无码婬AAAA片 | 91麻豆久久一级中文字幕 | 国产熟妇XXXXX视频 | 成人午夜伦理福利电影 | 在线观看视频精品99 | 国产又爽又黄无码无遮在线观看 | 亚洲一区无码人妻 | 无码精品秘 蜜桃林思允 | 国产精品一区二区不卡 | 亚洲毛片高清无码在线观看 | 西西4444wwww大胆视频 | 和孩做爰A片免费播放 | 在线观看国产亚洲无码 | 90岁老太婆一级毛片在线播放 | 国产熟睡乱子伦午夜视频在线 | 黄色在线免费观看 | 欧美三级三级三级爽爽爽 | 最新中文字幕在线 | Xiao77熟女精品视频 | 动漫美女私密观看视频 | 四川乱子伦视频国产 | AV中文字幕在线观看 | 91在线无码精品秘 国产阿朱 | 肉乳乱无码A片观看免费 | 揉老女人老熟女三区 | 日韩内射美女人妻一区二区三区 | 欧美成人精品激情在线观看 |