產(chǎn)品編號(hào) | bs-4087R-Bio |
英文名稱 | Rabbit Anti-SPTLC1/Biotin Conjugated antibody |
中文名稱 | 生物素標(biāo)記的絲氨酸棕櫚酰轉(zhuǎn)移酶1抗體 |
別 名 | HSAN; HSAN1; HSN1; LBC1; LCB 1; LCB1; Long chain base biosynthesis protein 1; Serine C palmitoyltransferase; Serine palmitoyl CoA transferase 1; Serine palmitoyltransferase 1; Serine palmitoyltransferase long chain base subunit 1; Serine palmitoyltransferase subunit 1; SPT 1; SPT1; SPTI; SPTLC 1; SPTC1_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) 染色質(zhì)和核信號(hào) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, ) |
產(chǎn)品應(yīng)用 | WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 53kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SPTLC1 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013] Function: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Subunit: Heterodimer with SPTLC2 or SPTLC3. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SSSPTA or SSSPTB. Interacts with SPTSSA and SPTSSB; the interaction is direct. Interacts with ORMDL3. Subcellular Location: Endoplasmic reticulum membrane; Single-pass membrane protein Tissue Specificity: Widely expressed. Not detected in small intestine. DISEASE: Defects in SPTLC1 are the cause of hereditary sensory and autonomic neuropathy type 1A (HSAN1A) [MIM:162400]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN1A is an autosomal dominant axonal neuropathy with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations. Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Database links: Entrez Gene: 426145 Chicken Entrez Gene: 739412 Chimpanzee Entrez Gene: 100726468 Guinea pig Entrez Gene: 10558 Human Entrez Gene: 268656 Mouse Entrez Gene: 100344536 Rabbit Entrez Gene: 705324 Rhesus monkey Omim: 605712 Human SwissProt: Q60HD1 Cynomolgus Monkey SwissProt: O15269 Human SwissProt: O35704 Mouse Unigene: 90458 Human Unigene: 240336 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 在线观看黄色视频网站 | 国产毛A片午夜免费视频 | 色五月色婷婷开心五月 | 红桃视频成人在线观看 | 精品国产乱码一区二区三区 | 91丨国产丨白浆秘 喷淫网站 | 成人福利午夜A片公司 | ,国产乱人伦无码视频 | 国产精品a久久久久久 | 少妇无码无套AV一区 | 18国产又黄又爽又猛的A片 | 久久精品视频在线观看 | 欧美疯狂做受XXXX猛交 | 亚洲人成电影一区二区在线 | 蜜桃Av噜噜一区二区三区小说 | 亚洲国产91精品A∨无码 | 在线中文字幕观看视频 | 污黄视频在线观看免费 | 一级老太婆毛片免费播放 | 国产精品久久久久久久无码 | 美女性感黄色一级播放片 | 免费AV一区二区三区 | 一区二区免费视频 | 亚洲第一视频在线播放 | 亚洲一级Av无码毛片久久精品 | 精品国产乱码久久久久久1区2区-亚洲 | 欧美一区二区鲁丝袜片 | 国产一区二区三区免费播放 | 奇米精品一区二区三区在线观看 | 7777色情网黄A片免费看蜜臀 | 人妻熟妇久久久久久XXX | 精品人妻一区二区三区阅读全文 | 成年人在线观看视频 | 红桃视频无码中文精品 | 少妇做爰免费8级A片 | 7777理论片免费播放 | 蜜桃视频一区二区三区四区软件介绍 | 国产色情性黄 片视频免费视频 | 国产农村一级特黄妇女A片一 | 四川妇BBB桑BBB桑BBB |