| 產(chǎn)品編號 | bs-1896R-Bio |
| 英文名稱 | Rabbit Anti-SOCS2/Biotin Conjugated antibody |
| 中文名稱 | 生物素標(biāo)記的細(xì)胞因子信號傳導(dǎo)抑制蛋白2抗體 |
| 別 名 | suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; SOCS 2; Cish2; SSI-2; STATI2; SOCS2_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Socs 2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Subunit: Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. Tissue Specificity: High expression in heart, placenta, lung, kidney and prostate. Similarity: Contains 1 SH2 domain. Contains 1 SOCS box domain. Database links: Entrez Gene: 8835 Human Entrez Gene: 216233 Mouse Omim: 605117 Human SwissProt: O14508 Human SwissProt: O35717 Mouse Unigene: 485572 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 細(xì)胞因子信號傳導(dǎo)抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一類由細(xì)胞產(chǎn)生并反饋性阻斷細(xì)胞因子信號轉(zhuǎn)導(dǎo)過程的負(fù)性調(diào)節(jié)因子，SOCS2可抑制IL-6、LIF、OSM、INF-γ以及GH等多種細(xì)胞因子的信號轉(zhuǎn)導(dǎo)，對體內(nèi)多種免疫反應(yīng)的激活起調(diào)控作用。SOCS2異常表達(dá)與多種疾病的發(fā)病相關(guān)，在急慢性白血病、類風(fēng)濕性關(guān)節(jié)炎、肝硬化和肝癌的發(fā)病中起重要作用；對信號轉(zhuǎn)導(dǎo)，特別是JAKSTAT通路的負(fù)調(diào)控作用已被肯定。 |
