| 產(chǎn)品編號 | bs-1285R-BF488 |
| 英文名稱 | Rabbit Anti-ETS1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的轉(zhuǎn)錄因子家族ETS1抗體 |
| 別 名 | Avian erythroblastosis virus E26 (v ets) oncogene homolog 1; C ets 1 protein; ETS 1; Ets protein; ETS-1; ETS1 protein; ETS1_HUMAN; EWSR 2; EWSR2; FLJ10768; p54; Protein C-ets-1; v ets avian erythroblastosis virus E2 oncogene homolog; v ets avian erythroblastosis virus E26 oncogene homolog 1; v ets erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G) |
| 產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Ets1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Function: Transcription factor. Subunit: Interacts with MAF and MAFB. Interacts with PAX5, the interaction alters DNA-binding properties. Binds to DAXX. Interacts with UBE2I. Subcellular Location: Nucleus. Post-translational modifications: Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity. Ubiquitinated; which induces proteasomal degradation. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. Database links: Entrez Gene: 2113 Human Entrez Gene: 23871 Mouse Omim: 164720 Human SwissProt: P13474 Chicken SwissProt: P15062 Chicken SwissProt: P14921 Human SwissProt: P27577 Mouse Unigene: 369438 Human Unigene: 292415 Mouse Unigene: 88756 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Ets家族成員在胚胎發(fā)生早期的血細(xì)胞生成和血管發(fā)生及胚胎發(fā)育后期的組織發(fā)生中發(fā)揮重要的調(diào)控作用. 成年后Ets在許多組織，如造血組織、血管、腦和中樞神經(jīng)系統(tǒng)、乳腺、子宮內(nèi)膜、卵巢、睪丸、腎和肺中均有表達(dá). 由于Ets轉(zhuǎn)錄因子不同成員在胚胎發(fā)育過程中的特異性的表達(dá)與其功能關(guān)系密切。 Ets家族的重要成員Ets-1的表達(dá)與胰腺癌、甲狀腺癌、乳腺癌、胃癌、子宮內(nèi)膜癌、口腔鱗癌、肝細(xì)胞性肝癌(HCC)的發(fā)生、轉(zhuǎn)移有很重要的關(guān)系。 |
